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1. WO2011097595 - METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION

Publication Number WO/2011/097595
Publication Date 11.08.2011
International Application No. PCT/US2011/023950
International Filing Date 07.02.2011
IPC
A61K 9/70 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases
A61K 45/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
C07K 14/54 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
CPC
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61K 2039/55527
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55522Cytokines; Lymphokines; Interferons
55527Interleukins
A61K 2039/6093
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6093Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
A61K 38/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • UNIVERSITY OF ROCHESTER [US]/[US] (AllExceptUS)
  • BECK, Lisa, A. [US]/[US] (UsOnly)
  • DE BENEDETTO, Anna [IT]/[US] (UsOnly)
Inventors
  • BECK, Lisa, A.
  • DE BENEDETTO, Anna
Agents
  • MERKEL, Edwin, V.
Priority Data
61/302,02205.02.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION
(FR) PROCÉDÉS D'UTILISATION D'AGENTS QUI MODULENT L'EXPRESSION DE LA CLAUDINE
Abstract
(EN) This invention relates to the use of agents that modulate claudin-l and/or -23 expression or activity for purposes of regulating tight junction ("TJ") formation among keratinocytes that express claudin-l and/or -23, or other cell types that over- or under-express claudin-l and/or -23. Several aspects of the present invention relate to increasing claudin-l and/or -23 expression or function to enhance tight junction formation among claudin-l and/or -23 expressing cells, particularly keratinocyte and antigen presenting cells. Several other aspects of the invention relate to decreasing claudin-l and/or -23 expression or function to diminish tight junction formation among claudin-l and/or -23 expressing cells, particularly keratinocytes and antigen presenting cells. Transdermal drug and vaccine fomulations including agent(s) that decrease -1 and/or -23 expression or function to diminish tight junction formation among claudin-l and/or -23 expressing cells, as well as a trans dermal patch for delivering the same, are also included.
(FR) La présente invention concerne l'utilisation d'agents qui modulent l'expression ou l'activité de la claudine-l et/ou -23 dans le but de réguler la formation de jonction serrée (« TJ ») parmi les kératinocytes qui expriment la claudine-l et/ou -23, ou d'autres types de cellules qui sur-expriment ou sous-expriment la claudine-l et/ou -23. Plusieurs aspects de la présente invention concernent l'augmentation de l'expression ou de la fonction de la claudine-l et/ou -23 afin d'améliorer la formation de jonction serrée parmi les cellules exprimant la claudine-l et/ou -23, en particulier les kératinocytes et les cellules présentatrices de l'antigène. Plusieurs autres aspects de l'invention concernent la diminution de l'expression ou de la fonction de la claudine-l et/ou -23 afin de diminuer la formation de jonction serrée parmi les cellules d'expression de claudine-l et/ou -23, en particulier les kératinocytes et les cellules présentatrices de l'antigène. L'invention porte en outre sur des médicaments transdermiques et sur des formulations de vaccins qui comprennent un ou des agents diminuant l'expression ou la fonction -1 et/ou -23, afin de réduire la formation de jonction serrée parmi les cellules d'expression de claudine-l et/ou -23, L'invention porte également sur un timbre transdermique destiné à les administrer.
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