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1. WO2011097216 - VACCINE AND METHODS OF USE AGAINST STRONGYLOIDES STERCORALIS INFECTION

Publication Number WO/2011/097216
Publication Date 11.08.2011
International Application No. PCT/US2011/023320
International Filing Date 01.02.2011
IPC
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/435 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
CPC
A61K 39/0003
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0003Invertebrate antigens
A61P 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
C07K 14/4354
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
43536from worms
4354from nematodes
Applicants
  • THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]/[US] (AllExceptUS)
  • THOMAS JEFFERSON UNIVERSITY [US]/[US] (AllExceptUS)
  • NUTMAN, Thomas, B. [US]/[US] (UsOnly)
  • ABRAHAM, David [US]/[US] (UsOnly)
Inventors
  • NUTMAN, Thomas, B.
  • ABRAHAM, David
Agents
  • JAY, Jeremy, M.
Priority Data
61/301,42604.02.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) VACCINE AND METHODS OF USE AGAINST STRONGYLOIDES STERCORALIS INFECTION
(FR) VACCIN ET PROCÉDÉS D'UTILISATION CONTRE UNE INFECTION PAR STRONGYLOIDES STERCORALIS
Abstract
(EN) The polynucleotide encoding the SSIR gene from the nematode Strongyloides stercoralis is provided, along with the polypeptide encoded by the SSIR gene. It was found that when mice were immunized with the SSIR polypeptide vaccine, it provided immunity to mice which were implanted with Strongyloides stercoralis L3 implants. Methods for making the SSIR protein, recombinant vectors encoding the SSIR gene, a vaccine made from the SSIR protein, and methods of use are also provided.
(FR) La présente invention concerne un polynucléotide codant pour le gène SSIR du nématode Strongyloides stercoralis, ainsi que le polypeptide codé par le gène SSIR. Il a été observé que lorsque des souris sont immunisées avec le vaccin de polypeptide SSIR, cela confère une immunité aux souris qui ont été implantées avec des implants de Strongyloides stercoralis L3. La présente invention concerne en outre des procédés pour préparer la protéine SSIR, des vecteurs recombinants codant pour le gène SSIR, un vaccin préparé à partir de la protéine SSIR, et des procédés d'utilisation.
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