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1. WO2011092199 - MUTATED XMRV ENV PROTEINS IN THE IMMUNOSUPPRESSIVE DOMAIN

Publication Number WO/2011/092199
Publication Date 04.08.2011
International Application No. PCT/EP2011/051062
International Filing Date 26.01.2011
IPC
C07K 14/15 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
C12N 7/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
C12N 2740/13022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740Reverse Transcribing RNA Viruses
00011Reverse Transcribing RNA Viruses
10011Retroviridae
13011Gammaretrovirus, e.g. murine leukeamia virus
13022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N 2740/13061
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740Reverse Transcribing RNA Viruses
00011Reverse Transcribing RNA Viruses
10011Retroviridae
13011Gammaretrovirus, e.g. murine leukeamia virus
13061Methods of inactivation or attenuation
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants
  • INSTITUT GUSTAVE ROUSSY [FR]/[FR] (AllExceptUS)
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR]/[FR] (AllExceptUS)
  • UNIVERSITE PARIS-SUD XI [FR]/[FR] (AllExceptUS)
  • VIROXIS S.A.S. [FR]/[FR] (AllExceptUS)
  • HEIDMANN, Thierry [FR]/[FR] (UsOnly)
  • SCHLECHT-LOUF, Géraldine [FR]/[FR] (UsOnly)
Inventors
  • HEIDMANN, Thierry
  • SCHLECHT-LOUF, Géraldine
Agents
  • GROSSET-FOURNIER, Chantal
Priority Data
61/298,32826.01.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MUTATED XMRV ENV PROTEINS IN THE IMMUNOSUPPRESSIVE DOMAIN
(FR) PROTÉINES D'ENVELOPPE DU VIRUS XMRV PRÉSENTANT UNE MUTATION AU NIVEAU DE LEUR DOMAINE IMMUNOSUPPRESSEUR
Abstract
(EN)
The present invention relates to a mutated XMRV ENV protein in which the immunosuppressive domain of the wild type XMRV ENV protein presents at least one mutation, said immunosuppressive domain of the wild type XMRV ENV protein consisting of the amino acid sequence SEQ ID NO: 1, (LQNRRGLDILFLKEGGLCAA), said at least one mutation being such that E which is at the position 14 of SEQ ID NO :1 is substituted by R, H or K.
(FR)
La présente invention concerne une protéine d'enveloppe mutée du virus XMRV dans laquelle le domaine immunosuppresseur de la protéine d'enveloppe du virus XMRV de phénotype sauvage présente au moins une mutation, ledit domaine immunosuppresseur de la protéine d'enveloppe du virus XMRV de phénotype sauvage étant constitué de la séquence d'acides aminés SEQ ID NO : 1 (LQNRRGLDILFLKEGGLCAA), et ladite mutation faisant que E en position 14 de SEQ ID NO : 1 est remplacé par R, H ou K.
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