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1. (WO2011091213) REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2011/091213 International Application No.: PCT/US2011/021982
Publication Date: 28.07.2011 International Filing Date: 21.01.2011
IPC:
C07D 239/42 (2006.01) ,C07C 233/78 (2006.01) ,A61K 31/505 (2006.01) ,A61P 35/00 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
42
One nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
78
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
ACETYLON PHARMACEUTICALS INC. [US/US]; 70 Fargo Street , Suite 205 Boston, MA 02210, US (AllExceptUS)
VAN DUZER, John, H. [US/US]; US (UsOnly)
MAZITSCHEK, Ralph [DE/US]; US (UsOnly)
OGIER, Walter [US/US]; US (UsOnly)
BRADNER, James, Elliott [US/US]; US (UsOnly)
HUANG, Guoxiang [US/US]; US (UsOnly)
XIE, Dejian [CN/CN]; CN (UsOnly)
YU, Nan [CN/CN]; CN (UsOnly)
Inventors:
VAN DUZER, John, H.; US
MAZITSCHEK, Ralph; US
OGIER, Walter; US
BRADNER, James, Elliott; US
HUANG, Guoxiang; US
XIE, Dejian; CN
YU, Nan; CN
Agent:
TRINQUE, Brian, C..; Lathrop & Gage LLP 28State Street Boston, MA 02109, US
Priority Data:
61/336,46022.01.2010US
Title (EN) REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
(FR) COMPOSÉS AMIDE INVERSE EN TANT QU'INHIBITEURS DE PROTÉINE DÉSACÉTYLASE ET PROCÉDÉS D'UTILISATION ASSOCIÉS
Abstract:
(EN) The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
(FR) La présente invention a pour objet de nouveaux composés « amide inverse » comprenant un groupe chélateur de zinc, et l'utilisation de tels composés dans l'inhibition de HDAC6 et dans le traitement de différentes maladies, de différents troubles ou états pathologiques associés à HDAC6.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
RSP-2016/0849EP2526093IL221056JP2013518050SG182646CA2787756
EA201290677MX2012008553CL2012002026SG10201500444TKR1020120118480CN102933558
IL242867BR112012018246CN105727298CN105753739JP2016153425NZ601655
EP3091004AU2011207289DK2526093ES2592278AU2016213729ID2013/01525
PH1/2012/501492TH151341IN1913/KOLNP/2012PT2526093