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1. WO2011091134 - COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF METABOLIC DISORDERS

Publication Number WO/2011/091134
Publication Date 28.07.2011
International Application No. PCT/US2011/021855
International Filing Date 20.01.2011
IPC
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 33/50 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
C07K 14/70567
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US] (AllExceptUS)
  • SPIEGELMAN, Bruce, M. [US]/[US] (UsOnly)
  • CHOI, Jang, Hyun [KR]/[US] (UsOnly)
  • KAJIMURA, Shingo [JP]/[US] (UsOnly)
  • BANKS, Alexander [US]/[US] (UsOnly)
Inventors
  • SPIEGELMAN, Bruce, M.
  • CHOI, Jang, Hyun
  • KAJIMURA, Shingo
  • BANKS, Alexander
Agents
  • SMITH, DeAnn F.
Priority Data
61/336,48322.01.2010US
61/341,45531.03.2010US
61/399,97521.07.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF METABOLIC DISORDERS
(FR) COMPOSITIONS, KITS, ET PROCÉDÉS D'IDENTIFICATION, D'ÉVALUATION, DE PRÉVENTION, ET DE THÉRAPIE DE TROUBLES MÉTABOLIQUES
Abstract
(EN) The invention provides methods and compositions for selectively promoting anti- metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.
(FR) La présente invention concerne des procédés et des compositions destinés à favoriser de manière sélective l'activité anti-trouble métabolique par rapport à l'activation du PPAR gamma par le biais de la modulation de la phosphorylation du PPAR gamma (par exemple, la phosphorylation de la Ser-273 du récepteur activé par les proliférateurs des péroxysomes gamma de souris (PPAR gamma) 2 ou d'un résidu correspondant de sérine dans un homologue de PPAR gamma 2 de souris, y compris un humain). L'invention concerne également des procédés destinés à prévenir, à traiter, ou à prédire la faculté de réponse aux thérapies des troubles métaboliques chez un sujet par le biais d'une inhibition sélective d'une telle phosphorylation du PPAR gamma. L'invention concerne en outre des procédés d'identification de composés qui sont capables de moduler une telle phosphorylation du PPAR gamma.
Latest bibliographic data on file with the International Bureau