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1. WO2011091078 - ANTIBODY FC VARIANTS WITH ENHANCED COMPLEMENT ACTIVITY

Publication Number WO/2011/091078
Publication Date 28.07.2011
International Application No. PCT/US2011/021767
International Filing Date 19.01.2011
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
CPC
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
C07K 16/2878
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2878against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
C07K 16/2887
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2887against CD20
C07K 2317/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
C07K 2317/524
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
524CH2 domain
C07K 2317/72
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
72Increased effector function due to an Fc-modification
Applicants
  • XENCOR, INC. [US]/[US] (AllExceptUS)
  • LAZAR, Gregory, A. [US]/[US] (UsOnly)
  • KARKI, Sher, Bahadur [NE]/[US] (UsOnly)
  • MOORE, Gregory, L. [US]/[US] (UsOnly)
Inventors
  • LAZAR, Gregory, A.
  • KARKI, Sher, Bahadur
  • MOORE, Gregory, L.
Agents
  • KLINE, Gregory, H.
Priority Data
61/296,31619.01.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODY FC VARIANTS WITH ENHANCED COMPLEMENT ACTIVITY
(FR) VARIANTS D'ANTICORPS POSSÉDANT UNE ACTIVITÉ COMPLÉMENTAIRE ACCRUE
Abstract
(EN)
The present invention relates to novel Fc variants that comprise at least one novel amino acid residue which may provide for enhanced effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc receptor or ligand (e.g., Fc gamma R, C1q). Additionally, the Fc variants have altered complement dependent cytotoxicity (CDC) activity and/or antibody-dependent cell-mediated cytotoxicity (ADCC). The invention further provides methods and protocols for the application of said Fc variants, particularly for therapeutic purposes.
(FR)
La présente invention a pour objet de nouveaux variants Fc qui comprennent au moins un nouveau résidu d'acide aminé qui peuvent fournir une fonction d'effecteur accrue. Plus spécifiquement, la présente invention concerne des variants Fc qui ont une affinité de liaison modifiée pour un ou plusieurs récepteurs ou ligands Fc (par exemple, le Fc gamma R, C1q). En outre, les variants Fc ont une activité de cytotoxicité dépendante complémentaire (CDC) et/ou une cytotoxicité médiée par les cellules dépendante des anticorps (ADCC) modifiée. La présente invention concerne en outre des méthodes et des protocoles pour l'application desdits variants Fc, en particulier à des fins thérapeutiques.
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