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1. WO2011086053 - TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF

Publication Number WO/2011/086053
Publication Date 21.07.2011
International Application No. PCT/EP2011/050239
International Filing Date 11.01.2011
IPC
C07D 471/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
C07D 487/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 11/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
CPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
  • BABU, Srinivasan [US]/[US] (UsOnly)
  • BERGERON, Phillippe [CA]/[US] (UsOnly)
  • DRAGOVICH, Peter [US]/[US] (UsOnly)
  • DYKE, Hazel Joan [GB]/[GB] (UsOnly)
  • GIBBONS, Paul [US]/[US] (UsOnly)
  • GRADL, Stefan [DE]/[US] (UsOnly)
  • HANAN, Emily [US]/[US] (UsOnly)
  • HURLEY, Christopher [GB]/[GB] (UsOnly)
  • JOHNSON, Tony [GB]/[GB] (UsOnly)
  • KOEHLER, Michael [US]/[US] (UsOnly)
  • KULAGOWSKI, Janusz Josef [GB]/[GB] (UsOnly)
  • LABADIE, Sharada Shenvi [US]/[US] (UsOnly)
  • LYSSIKATOS, Joseph P. [US]/[US] (UsOnly)
  • MENDONCA, Rohan [US]/[US] (UsOnly)
  • PULK, Rebecca [US]/[US] (UsOnly)
  • WARD, Stuart [GB]/[GB] (UsOnly)
  • WASZKOWYCZ, Bohdan [GB]/[GB] (UsOnly)
  • ZAK, Mark [CA]/[US] (UsOnly)
Inventors
  • BABU, Srinivasan
  • BERGERON, Phillippe
  • DRAGOVICH, Peter
  • DYKE, Hazel Joan
  • GIBBONS, Paul
  • GRADL, Stefan
  • HANAN, Emily
  • HURLEY, Christopher
  • JOHNSON, Tony
  • KOEHLER, Michael
  • KULAGOWSKI, Janusz Josef
  • LABADIE, Sharada Shenvi
  • LYSSIKATOS, Joseph P.
  • MENDONCA, Rohan
  • PULK, Rebecca
  • WARD, Stuart
  • WASZKOWYCZ, Bohdan
  • ZAK, Mark
Agents
  • BEYERMANN, Jochen
Priority Data
61/294,40412.01.2010US
61/366,78522.07.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
(FR) COMPOSÉS HÉTÉROCYCLIQUES TRICYCLIQUES, LEURS COMPOSITIONS ET PROCÉDÉS D'UTILISATION
Abstract
(EN) The invention provides novel compounds of formula (I) having the general formula, wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
(FR) La présente invention concerne de nouveaux composés de formule (I) ayant la formule générale, dans laquelle R1, R2, R3, X et Y sont tels que décrits ici. Par conséquent, les composés peuvent être fournis dans des compositions pharmaceutiquement acceptables et utilisés pour traiter des troubles immunologiques ou hyperprolifératifs.
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