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1. (WO2011085979) USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/085979 International Application No.: PCT/EP2011/000110
Publication Date: 21.07.2011 International Filing Date: 13.01.2011
IPC:
C07D 307/93 (2006.01) ,A61K 31/343 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/06 (2006.01) ,A61K 8/49 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
93
condensed with a ring other than six-membered
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343
condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
06
Antihyperlipidemics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
49
containing heterocyclic compounds
Applicants:
GROTHE, Torsten [DE/DE]; DE (UsOnly)
ROEMER, Ernst [DE/DE]; DE (UsOnly)
WABNITZ, Philipp [DE/DE]; DE (UsOnly)
INTERMED DISCOVERY GMBH [DE/DE]; Otto-Hahn-Str. 15 44227 Dortmund, DE (AllExceptUS)
Inventors:
GROTHE, Torsten; DE
ROEMER, Ernst; DE
WABNITZ, Philipp; DE
Agent:
MAUCHER, Wolfgang; Urachstrasse 23 79102 Freiburg i. Br., DE
Priority Data:
10 000 282.314.01.2010EP
Title (EN) USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS
(FR) UTILISATION DE SESQUITERPÈNE-LACTONES TRICYCLIQUES DANS LE TRAITEMENT DE L'OBÉSITÉ, DE MALADIES ASSOCIÉES ET DE TROUBLES NON THÉRAPEUTIQUEMENT TRAITABLES
Abstract:
(EN) A compound of the formula I, wherein the symbols are as defined in the remaining specification, or a mixture of two or more compounds of the formula I, for use as active ingredient in the therapeutic - including prophylactic - treatment of a warm-blooded animal for the regulation of body weight (preferred) and/or fat loss (preferred) and/or for the management of obesity and/or for improving the total cholesterol HDL/LDL ratio; where the compound(s) of the formula I may be present in free form, in the form of a pharmaceutically and/or nutraceutically acceptable salt, in the form of tautomers, in the form of esters and/or in the form of solvates, as well as related invention embodiments.
(FR) La présente invention concerne un composé de formule I, dans laquelle les symboles sont tels que définis dans le reste de la spécification, ou un mélange d'au moins deux composés de formule I, à utiliser en tant que principe actif dans le traitement thérapeutique, y compris prophylactique, d'un animal à sang chaud pour la régulation du poids corporel (préféré) et/ou de la perte de graisses (préféré) et/ou pour la prise en charge de l'obésité et/ou pour améliorer le rapport de cholestérol HDL/LDL total; où le(s) composé(s) de formule I peu(ven)t être présent(s) sous forme libre, sous la forme d'un sel acceptable sur le plan pharmaceutique et/ou nutraceutique, sous la forme de tautomères, sous la forme d'esters et/ou sous la forme de solvates, ainsi que des modes de réalisation de l'invention associés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)