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1. WO2011075656 - METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS

Publication Number WO/2011/075656
Publication Date 23.06.2011
International Application No. PCT/US2010/061058
International Filing Date 17.12.2010
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 9/133 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
133Unilamellar vesicles
CPC
A61K 47/543
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
543Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
A61K 47/6911
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905the form being a colloid or an emulsion
6911the form being a liposome
A61K 9/1272
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
1272with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C12N 15/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88using microencapsulation, e.g. using ; amphiphile; liposome vesicle
Applicants
  • THE UNIVERSITY OF BRITISH COLUMBIA [CA]/[CA] (AllExceptUS)
  • ALNYLAM PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • HOPE, Michael, J. [CA]/[CA] (UsOnly)
  • MADDEN, Thomas, D. [CA]/[CA] (UsOnly)
  • CULLIS, Pieter [CA]/[CA] (UsOnly)
  • MAIER, Martin, A. [DE]/[US] (UsOnly)
  • JAYARAMAN, Muthusamy [IN]/[US] (UsOnly)
  • RAJEEV, Kallanthottathil, G. [IN]/[US] (UsOnly)
  • AKINC, Akin [US]/[US] (UsOnly)
  • MANOHARAN, Muthiah [US]/[US] (UsOnly)
Inventors
  • HOPE, Michael, J.
  • MADDEN, Thomas, D.
  • CULLIS, Pieter
  • MAIER, Martin, A.
  • JAYARAMAN, Muthusamy
  • RAJEEV, Kallanthottathil, G.
  • AKINC, Akin
  • MANOHARAN, Muthiah
Agents
  • FOX, Harold, H.
Priority Data
61/287,99518.12.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS
(FR) PROCÉDÉS ET COMPOSITIONS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
Abstract
(EN)
A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.
(FR)
Une particule lipidique peut comprendre une pluralité de lipides cationiques, tels qu'un premier lipide cationique et un second lipide cationique. Le premier lipide cationique peut être choisi sur la base d'une première propriété et le second lipide cationique peut être choisi sur la base d'une seconde propriété. Les première et seconde propriétés sont complémentaires. Les qualités de la particule lipidique peuvent refléter les propriétés sélectionnées des lipides cationiques, et la nature complémentaire de ces propriétés.
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