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1. (WO2011073263) 1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/073263 International Application No.: PCT/EP2010/069771
Publication Date: 23.06.2011 International Filing Date: 15.12.2010
IPC:
C07D 471/14 (2006.01) ,A61K 31/4427 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
DYKE, Hazel Joan [GB/GB]; GB (UsOnly)
GAZZARD, Lewis J. [GB/US]; US (UsOnly)
WILLIAMS, Karen [GB/GB]; GB (UsOnly)
CHEN, Huifen [US/US]; US (UsOnly)
KINTZ, Samuel [US/US]; US (UsOnly)
DROBNICK, Joy [US/US]; US (UsOnly)
LYSSIKATOS, Joseph P. [US/US]; US (UsOnly)
GOODACRE, Simon [GB/GB]; GB (UsOnly)
MACLEOD, Calum [GB/GB]; GB (UsOnly)
ELLWOOD, Charles [GB/GB]; GB (UsOnly)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
Inventors:
DYKE, Hazel Joan; GB
GAZZARD, Lewis J.; US
WILLIAMS, Karen; GB
CHEN, Huifen; US
KINTZ, Samuel; US
DROBNICK, Joy; US
LYSSIKATOS, Joseph P.; US
GOODACRE, Simon; GB
MACLEOD, Calum; GB
ELLWOOD, Charles; GB
Agent:
SCHIRLIN, Julien; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
61/284,41416.12.2009US
61/287,70217.12.2009US
Title (EN) 1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER
(FR) 1,7-DIAZACARBAZOLES ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
Abstract:
(EN) The invention relates to 1, 7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk 1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
(FR) Cette invention concerne des composés de 1,7-diazacarbazole de Formule (I), (I-a) et (I-b) qui sont utiles à titre d'inhibiteurs de kinase, plus spécifiquement, qui sont utiles à titre d'inhibiteurs de la checkpoint kinase 1 (chk 1), et par conséquent, utiles à titre d'anticancéreux. Cette invention concerne également des compositions, plus spécifiquement, des compositions pharmaceutiques contenant lesdits composés et des méthodes les utilisant pour traiter diverses formes de cancer et autres troubles hyperprolifératifs, ainsi que des méthodes d'utilisation des composés selon l'invention pour le diagnostic ou le traitement in vitro, in situ, et in vivo de cellules de mammifères, ou d'affections pathologiques associées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)