Processing

Please wait...

Settings

Settings

Goto Application

1. WO2011073214 - A METHOD FOR IDENTIFYING HETERO-MULTIMERIC MODIFIED UBIQUITIN PROTEINS WITH BINDING CAPABILITY TO LIGANDS

Publication Number WO/2011/073214
Publication Date 23.06.2011
International Application No. PCT/EP2010/069674
International Filing Date 14.12.2010
IPC
C07K 14/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C12N 15/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
C40B 40/02 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/435
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/525
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
525Tumour necrosis factor [TNF]
C07K 2319/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
31fusions, other than Fc, for prolonged plasma life, e.g. albumin
C07K 2319/95
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
95containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
Applicants
  • SCIL PROTEINS GMBH [DE]/[DE] (AllExceptUS)
  • KUNERT, Anja [DE]/[DE] (UsOnly)
  • NERKAMP, Jörg [DE]/[DE] (UsOnly)
  • STEUERNAGEL, Arnd [DE]/[DE] (UsOnly)
  • FIEDLER, Markus [DE]/[DE] (UsOnly)
  • FIEDLER, Erik [DE]/[DE] (UsOnly)
  • GÖTTLER, Thomas [DE]/[DE] (UsOnly)
Inventors
  • KUNERT, Anja
  • NERKAMP, Jörg
  • STEUERNAGEL, Arnd
  • FIEDLER, Markus
  • FIEDLER, Erik
  • GÖTTLER, Thomas
Agents
  • BEHNISCH, Werner
Priority Data
09179147.514.12.2009EP
10162264.507.05.2010EP
10186980.808.10.2010EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD FOR IDENTIFYING HETERO-MULTIMERIC MODIFIED UBIQUITIN PROTEINS WITH BINDING CAPABILITY TO LIGANDS
(FR) PROCÉDÉ POUR IDENTIFIER DES PROTÉINES D'UBIQUITINE HÉTÉROMULTIMÉRIQUES MODIFIÉES AYANT LA CAPACITÉ DE SE LIER À DES LIGANDS
Abstract
(EN)
The present invention refers to a method for identifying hetero-multimeric ubiquitins with binding capability to a ligand. Furthermore, the invention provides DNA libraries encoding for a population of said hetero-multimeric ubiquitins as well as protein libraries obtained by expression of said DNA libraries, cells and phages containing said DNA or proteins, polynucleotides encoding for said fusion proteins and vectors comprising said polynucleotides. Further new binding proteins based on hetero-multimeric ubiquitin being able to bind specifically with high affinity to selected ligands are provided.
(FR)
Cette invention concerne un procédé pour identifier des ubiquitines hétéromultimériques ayant la capacité de se lier à un ligand. L'invention concerne, en outre, des banques d'ADN codant pour une population desdites ubiquitines hétéromultimériques ainsi que des banques de protéines obtenues par l'expression desdites banques d'ADN, des cellules et des phages contenant ledit ADN ou lesdites protéines, des polynucléotides codant pour lesdites protéines de fusion et des vecteurs comprenant lesdits polynucléotides. D'autres nouvelles protéines de liaison basées sur l'ubiquitine hétéromultimérique ayant la capacité de se lier spécifiquement et à une affinité élevée à des ligands sélectionnés sont décrites.
Latest bibliographic data on file with the International Bureau