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1. WO2011072484 - TARGET AND MEDICAMENTS FOR TREATMENT OF BRAIN INJURIES

Publication Number WO/2011/072484
Publication Date 23.06.2011
International Application No. PCT/CN2010/002044
International Filing Date 15.12.2010
IPC
A61K 38/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 31/7015
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CPC
A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
Applicants
  • 中国科学院上海生命科学研究院 SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CAS [CN]/[CN] (AllExceptUS)
  • 王以政 WANG, Yizheng [CN]/[CN] (UsOnly)
  • 杜婉璐 DU, Wanlu [CN]/[CN] (UsOnly)
  • 黄隽波 HUANG, Junbo [CN]/[CN] (UsOnly)
Inventors
  • 王以政 WANG, Yizheng
  • 杜婉璐 DU, Wanlu
  • 黄隽波 HUANG, Junbo
Agents
  • 上海专利商标事务所有限公司 SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC
Priority Data
200910201207.416.12.2009CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) TARGET AND MEDICAMENTS FOR TREATMENT OF BRAIN INJURIES
(FR) CIBLE ET MÉDICAMENTS POUR TRAITEMENT DE LÉSIONS CÉRÉBRALES
(ZH) 脑损伤治疗的靶点和药物
Abstract
(EN)
The invention discloses the substance used for treating or preventing the ischemic brain injuries or neurodegenerative diseases by sustaining the TRPC6 level of nerve cells. The substance may be calpain inhibitors, reinforcing agents of TRPC6 expression, or NMDA receptor antagonists. The invention also discloses the uses of said substance for manufacturing medicaments for preventing or treating ischemic brain injuries or neurodegenerative diseases.
(FR)
Cette invention concerne une substance utilisée pour traiter ou prévenir des lésions ischémiques cérébrales ou des maladies neurodégénératives, qui permet de soutenir le niveau de TROC6 des neurones. Ladite substance peut être constituée par des inhibiteurs de la calpaïne, des agents de renforcement de l'expression de TPRC6 ou des antagonistes du récepteur NMDA. L'invention concerne également des utilisations de ladite substance pour la fabrication de médicaments destinés à prévenir ou à traiter des lésions ischémiques cérébrales ou des maladies neurodégénératives.
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