WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
maximize
Machine translation
1. (WO2011069127) LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM HUMAN EMBRYONIC STEM CELLS UNDER STROMAL-FREE CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/069127    International Application No.:    PCT/US2010/058990
Publication Date: 09.06.2011 International Filing Date: 03.12.2010
IPC:
C12N 5/00 (2006.01), C12N 5/02 (2006.01)
Applicants: STEM CELL & REGENERATIVE MEDICINE INTERNATIONAL, INC. [US/US]; 33 Locke Drive Marlborough, Massachusetts 01752 (US) (For All Designated States Except US).
LI, Feng [CN/US]; (US) (For US Only).
LU, Shi-Jiang [CA/US]; (US) (For US Only)
Inventors: LI, Feng; (US).
LU, Shi-Jiang; (US)
Agent: TRUONG, Linda, B.; Davis Wright Tremaine LLP 865 South Figueroa Street Suite 2400 Los Angeles, California 90017 (US)
Priority Data:
61/266,939 04.12.2009 US
61/384,165 17.09.2010 US
Title (EN) LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM HUMAN EMBRYONIC STEM CELLS UNDER STROMAL-FREE CONDITIONS
(FR) PRODUCTION À GRANDE ÉCHELLE DE PLAQUETTES ET DE MÉGACARYOCYTES FONCTIONNELS PROVENANT DE CELLULES SOUCHES EMBRYONNAIRES HUMAINES, DANS DES CONDITIONS EXEMPTES DE STROMA
Abstract: front page image
(EN)The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion.
(FR)La présente invention concerne un procédé de production de mégacaryocytes et de plaquettes. Dans divers modes de réalisation, ledit procédé implique l'utilisation de cellules souches embryonnaires humaines dérivées d'hémangioblastes pour la différenciation en mégacaryocytes et en plaquettes dans des conditions exemptes de stroma et de sérum. Dans ce système, les hESC sont dirigées vers des mégacaryocytes par l'intermédiaire de la formation de corps embryoïdes et la différenciation d'hémangioblastes. En outre, la présente invention concerne une méthode de traitement d'un sujet ayant besoin d'une transfusion de plaquettes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)