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1. (WO2011069082) RED BLOOD CELL-MIMETIC PARTICLES AND METHODS FOR MAKING AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/069082 International Application No.: PCT/US2010/058921
Publication Date: 09.06.2011 International Filing Date: 03.12.2010
IPC:
A61K 47/48 (2006.01) ,A61K 47/30 (2006.01) ,A61K 9/24 (2006.01) ,A61K 9/52 (2006.01) ,A61K 49/18 (2006.01) ,A61K 49/08 (2006.01) ,A61K 35/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
24
Layered or laminated unitary dosage forms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
52
Sustained or differential release type
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18
characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
18
Erythrocytes
Applicants:
LAHANN, Joerg [DE/US]; US (UsOnly)
MITRAGOTRI, Samir [US/US]; US (UsOnly)
BHASKAR, Srijanani [IN/US]; US (UsOnly)
DOSHI, Nishit [IN/US]; US (UsOnly)
ZAHR, Alisar S. [US/US]; US (UsOnly)
THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; 1600 Huron Parkway, 2nd Floor Ann Arbor, Michigan 48109-2590, US (AllExceptUS)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street Twelfth Floor Oakland, California 94607-5200, US (AllExceptUS)
Inventors:
LAHANN, Joerg; US
MITRAGOTRI, Samir; US
BHASKAR, Srijanani; US
DOSHI, Nishit; US
ZAHR, Alisar S.; US
Agent:
WOODSIDE-WOJTALA, Jennifer M.; Harness, Dickey & Pierce, P.L.C. P.O. Box 828 Bloomfield Hills, Michigan 48303, US
Priority Data:
61/266,92704.12.2009US
Title (EN) RED BLOOD CELL-MIMETIC PARTICLES AND METHODS FOR MAKING AND USE THEREOF
(FR) PARTICULES MIMÉTIQUES DES ÉRYTHROCYTES ET LEURS PROCÉDÉS DE RÉALISATION ET D'UTILISATION
Abstract:
(EN) The present technology provides synthesized particles that mimic key structural and functional features of red blood cells. Such RBC-mimicking particles possess the ability to carry oxygen (and carbon dioxide) and flow through capillaries smaller than their own diameter. Further, such particles can also deliver drugs and imaging agents. These particles provide a new paradigm for the design of drug delivery and imaging carriers since they combine the functionality of natural RBCs with the broad applicability and versatility of synthetic drug delivery particles. Further, such particles can be used for detoxification and other biomedical applications.
(FR) La présente invention concerne des particules synthétisées qui imitent les caractéristiques structurelles et fonctionnelles essentielles des érythrocytes. De telles particules qui imitent les érythrocytes possèdent la capacité de transporter l'oxygène (et le dioxyde de carbone) et de s'écouler à travers des capillaires d'un diamètre inférieur à leur propre diamètre. En outre, de telles particules peuvent également administrer des médicaments et des agents d'imagerie. Lesdites particules offrent un nouveau paradigme pour la conception d'une administration de médicament et de supports d'imagerie, car elles combinent la fonctionnalité des érythrocytes naturels au vaste champ d'application et à la polyvalence de particules d'administration de médicaments synthétiques. En outre, ces particules peuvent être utilisées pour la détoxication et d'autres applications biomédicales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)