Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2011068723) ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/068723 International Application No.: PCT/US2010/057818
Publication Date: 09.06.2011 International Filing Date: 23.11.2010
IPC:
A61K 9/20 (2006.01) ,A61K 9/14 (2006.01) ,A61K 31/277 (2006.01) ,A61K 31/167 (2006.01) ,A61K 31/192 (2006.01) ,A61K 31/485 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
277
having a ring, e.g. verapamil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
Applicants:
ROTH, Wolfgang [DE/DE]; DE (UsOnly)
BURST, Alexander [DE/DE]; DE (UsOnly)
ZIETSCH, Martina [DE/DE]; DE (UsOnly)
LIU, Wei [CN/US]; US (UsOnly)
DUTTA, Sandeep [IN/US]; US (UsOnly)
ABBOTT LABORATORIES [US/US]; 100 Abbott Park Road Abbott Park, Illinois 60064, US (AllExceptUS)
ABBOTT GMBH & CO.KG [DE/DE]; Max-Planck-Ring 2 65205 Wiesbaden-Delkenhim, DE (AllExceptUS)
Inventors:
ROTH, Wolfgang; DE
BURST, Alexander; DE
ZIETSCH, Martina; DE
LIU, Wei; US
DUTTA, Sandeep; US
Agent:
PARIAL, Andrew M.; Abbott Laboratories 100 Abbott Park Road AP6A-1/D0377 Abbott Park, Illinois 60064, US
Priority Data:
12/631,01004.12.2009US
Title (EN) ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION
(FR) PRÉPARATION EXTRUDÉE PAR FUSION, À POUVOIR ADDICTIF RÉDUIT ET AYANT UNE INTERACTION RÉDUITE AVEC L'ALCOOL
Abstract:
(EN) The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse - resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. The dosage form can include verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non- abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non -abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
(FR) Cette invention concerne des compositions administrées par voie orale. L'invention comporte de préférence au moins une composition à pouvoir addictif réduit qui administre un médicament présentant un risque de libération massive au contact de l'alcool, des procédés associés de préparation de ces formes pharmaceutiques, et des procédés de traitement d'un patient nécessitant ce médicament, consistant à administrer les compositions de l'invention au patient. La forme pharmaceutique comprend du vérapamil. Ces préparations présentent un risque réduit de surdosage. Dans une autre préparation, le médicament à risque de surdosage est de préférence un opioïde et le médicament sans risque de surdosage est l'acétaminophène ou l'ibuprofène. L'opioïde est de préférence l'hydrocodone, et l'analgésique sans risque de surdosage est le l'acétaminophène. Dans certains modes de réalisation préférés, les formes pharmaceutiques se caractérisent par leur résistance à l'extraction par solvant, au tassement, à l'écrasement ou au broyage. Certains modes de réalisation de l'invention concernent des formes pharmaceutiques produisant une première libération du médicament, puis une libération contrôlée du médicament sur une période prolongée.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)