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1. (WO2011064549) COMPOSITION AND METHOD FOR DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2011/064549 International Application No.: PCT/GB2010/002184
Publication Date: 03.06.2011 International Filing Date: 26.11.2010
Chapter 2 Demand Filed: 11.10.2011
IPC:
C12N 5/0735 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
073
Embryonic cells or tissues; Foetal cells or tissues
0735
Embryonic stem cells; Embryonic germ cells
Applicants:
STEM CELLS FOR SAFER MEDICINES LIMITED [GB/GB]; c/o BPE Solicitors LLP PO Box 1st Floor, St James House St James Square Cheltenham Gloucestershire GL50 3PR, GB (AllExceptUS)
BONE, Heather Karyn [GB/GB]; GB (UsOnly)
TOSH, David [GB/GB]; GB (UsOnly)
WELHAM, Melanie Joanne [GB/GB]; GB (UsOnly)
Inventors:
BONE, Heather Karyn; GB
TOSH, David; GB
WELHAM, Melanie Joanne; GB
Agent:
LOCK, Graham, James; Fry Heath & Spence LLP The Gables Massetts Road Horley RH6 7DQ, GB
SWEETINBURGH, Mark Roger; Sweetinburgh & Windsor Ltd Unit 65, Basepoint, Metcalf Way Crawley, West Sussex RH11 7XX, GB
Priority Data:
0920865.327.11.2009GB
1002329.911.02.2010GB
Title (EN) COMPOSITION AND METHOD FOR DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
(FR) COMPOSITION ET PROCÉDÉ DE DIFFÉRENTIATION DE CELLULES SOUCHES EMBRYONNAIRES HUMAINES
Abstract:
(EN) Described are methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a cell or population of cells characteristic of the definitive endoderm, the method comprising incubating the cell or population of cells with a GSK-3 inhibitor. Also described are methods for inducing differentiation of a cell or population of cells, characteristic of the definitive endoderm, towards a hepatocyte-like cell or a population of hepatocyte-like cells, and methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a hepatocyte-like cell or a population of hepatocyte-like cells. Further described are cells obtained by the methods and uses thereof in therapy and toxicity screening.
(FR) La présente invention concerne des procédés d'induction de la différentiation d'une cellule souche embryonnaire humaine ou d'une population de cellules souches embryonnaires humaines en une cellule ou en une population de cellules caractéristique de l'endoderme définitif, ledit procédé impliquant l'incubation de la cellule ou de la population de cellules avec un inhibiteur de la GSK-3. L'invention concerne également des procédés d'induction de la différentiation d'une cellule ou d'une population de cellules, caractéristique de l'endoderme définitif, en une cellule de type hépatocytaire ou en une population de cellules de type hépatocytaire, ainsi que des procédés d'induction de la différentiation d'une cellule souche embryonnaire humaine ou d'une population de cellules souches embryonnaires humaines en une cellule de type hépatocytaire ou en une population de cellules de type hépatocytaire. L'invention concerne, en outre, des cellules obtenues par les procédés de l'invention et leurs utilisations dans le cadre de criblages thérapeutiques et de toxicité.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2470643US20130028872JP2013511974CN102834505IN4723/DELNP/2012