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1. (WO2011063005) METHODS OF PRODUCING HUMAN RPE CELLS AND PHARMACEUTICAL PREPARATIONS OF HUMAN RPE CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/063005    International Application No.:    PCT/US2010/057056
Publication Date: 26.05.2011 International Filing Date: 17.11.2010
IPC:
C12N 5/071 (2010.01), C12N 5/0735 (2010.01), C12N 5/02 (2006.01), A61K 35/44 (2006.01), A61P 27/02 (2006.01)
Applicants: ADVANCED CELL TECHNOLOGY, INC. [US/US]; 33 Locke Drive Marlborough, Massachusetts 01752 (US) (For All Designated States Except US).
MALCUIT, Christopher [US/US]; (US) (For US Only).
LEMIEUX, Linda [US/US]; (US) (For US Only).
HOLMES, William [US/US]; (US) (For US Only).
HUERTAS, Pedro [US/US]; (US) (For US Only).
VILNER, Lucy [US/US]; (US) (For US Only)
Inventors: MALCUIT, Christopher; (US).
LEMIEUX, Linda; (US).
HOLMES, William; (US).
HUERTAS, Pedro; (US).
VILNER, Lucy; (US)
Agent: TESKIN, Robin, L.; Hunton & Williams Intellectual Property Department 1900 K Street, N.W. Washington, District of Columbia 20006 (US)
Priority Data:
61/262,002 17.11.2009 US
Title (EN) METHODS OF PRODUCING HUMAN RPE CELLS AND PHARMACEUTICAL PREPARATIONS OF HUMAN RPE CELLS
(FR) PROCÉDÉS DE GÉNÉRATION DE CELLULES HUMAINES DE L'ÉPITHÉLIUM PIGMENTAIRE RÉTINIEN (RPE) ET PRÉPARATIONS PHARMACEUTIQUES DE CELLES-CI
Abstract: front page image
(EN)[0362] The present invention provides improved methods for producing retinal pigmented epithelial (RPE) cells from human embryonic stem cells, human induced pluripotent stem (iPS), human adult stem cells, human hematopoietic stem cells, human fetal stem cells, human mesenchymal stem cells, human postpartum stem cells, human multipotent stem cells, or human embryonic germ cells. The RPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The RPE cells described herein are useful for treating retinal degenerative conditions including retinal detachment and macular degeneration.
(FR)La présente invention porte sur des procédés améliorés de génération de cellules de l'épithélium pigmentaire rétinien (RPE) à partir de cellules souches humaines embryonnaires, de cellules souches humaines pluripotentes induites (iPS), de cellules souches humaines adultes, de cellules souches humaines hématopoïétiques, de cellules souches humaines fœtales, de cellules souches humaines mésenchymateuses, de cellules souches humaines post-partum, de cellules souches humaines pluripotentes, ou de cellules germinales humaines embryonnaires. Les cellules de l'épithélium pigmentaire rétinien (RPE) dérivées de cellules souches embryonnaires sont distinctes sur le plan moléculaire des cellules de l'épithélium pigmentaire rétinien (RPE) dérivées de cellules adultes et fœtales, et sont également distinctes des cellules souches embryonnaires. Les cellules RPE décrites ici sont utiles pour le traitement de maladies dégénératives de la rétine comprenant le décollement de la rétine et la dégénérescence maculaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)