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1. (WO2011061527) COMBINATIONS COMPRISING A GLUCOCORTICOID RECEPTOR MODULATOR FOR THE TREATMENT OF RESPIRATORY DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2011/061527 International Application No.: PCT/GB2010/051905
Publication Date: 26.05.2011 International Filing Date: 16.11.2010
IPC:
A61K 31/416 (2006.01) ,A61K 31/428 (2006.01) ,A61K 31/438 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/4468 (2006.01) ,A61K 31/4965 (2006.01) ,A61K 31/519 (2006.01) ,A61K 31/58 (2006.01) ,A61K 45/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
416
condensed with carbocyclic ring systems, e.g. indazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
428
condensed with carbocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
438
the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4468
having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58
containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants:
ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje, SE (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstrasse 178 DE-13353 Berlin, DE (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
ASTRAZENECA UK LIMITED [GB/GB]; 2 Kingdom Street London W2 6BD, GB (MG)
HANSSON, Thomas [SE/SE]; SE (UsOnly)
NILSSON, Stinabritt [SE/SE]; SE (UsOnly)
Inventors:
HANSSON, Thomas; SE
NILSSON, Stinabritt; SE
Agent:
ASTRAZENECA INTELLECTUAL PROPERTY; AstraZeneca AB S-151 85 Södertälje, SE
Priority Data:
61/261,83517.11.2009US
Title (EN) COMBINATIONS COMPRISING A GLUCOCORTICOID RECEPTOR MODULATOR FOR THE TREATMENT OF RESPIRATORY DISEASES
(FR) COMBINAISONS QUI COMPRENNENT UN MODULATEUR DU RÉCEPTEUR GLUCOCORTICOÏDE, DESTINÉES AU TRAITEMENT DE MALADIES RESPIRATOIRES
Abstract:
(EN) The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a glucocorticoid receptor modulator and a second active ingredient selected from an Adenosine A2A receptor antagonist, an anti-infective, an antioxidant, a β2 adrenoceptor agonist, a CCR1 antagonist, a chemokine antagonist, a muscarinic antagonist, a glucocorticosteroid, a CRTh2 antagonist, a DP1 antagonist, a formyl peptide receptor antagonist, a Histone Deacetylase activator, a chloride channel hCLCA1 blocker, an Epithelial sodium channel blocker, an Inter-cellular adhesion molecule 1 blocker, an IKK2 kinase inhibitor, a JNK kinase inhibitor, a COX inhibitor, a lipoxygenase inhibitor, a leukotriene receptor antagonist, a MEK-1 kinase inhibitor, a MPO inhibitor, a PDE4, inhibitor, a PI 3 kinase γ inhibitor, a PPARγ agonist, a protease inhibitor, a p38 inhibitor, a RARγ modulator, a statin, a thromboxane antagonist and a vasodilator; and its use in the treatment of respiratory disease.
(FR) La présente invention concerne un produit pharmaceutique, un kit ou une composition comprenant un premier principe actif qui est un modulateur du récepteur glucocorticoïde et un second principe actif sélectionné parmi un antagoniste du récepteur A2A de l'adénosine, un anti-infectieux, un antioxydant, un agoniste de l'adrénorécepteur β2, un antagoniste CCR1, un antagoniste de chimiokine, un antagoniste muscarinique, un glucocorticostéroïde, un antagoniste de CRTh2, un antagoniste de DP1, un antagoniste du récepteur du peptide formyle, un activateur d'histone déacétylase, un bloqueur hCLCA1 du canal chlorure, un bloqueur du canal sodique épithélial, un bloqueur de la molécule d'adhésion inter-cellulaire 1, un inhibiteur de la kinase IKK2, un inhibiteur de la kinase JNK, un inhibiteur de COX, un inhibiteur de lipoxygénase, un antagoniste du récepteur de leucotriène, un inhibiteur de la kinase MEK-1, un inhibiteur de MPO, un inhibiteur de PDE4, un inhibiteur de la kinase ? PI 3, un agoniste de PPARγ, un inhibiteur de protéase, un inhibiteur p38, un modulateur de RARγ, une statine, un antagoniste du thromboxane et un vasodilatateur. L'invention porte en outre sur leur utilisation dans le traitement de maladies respiratoires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)