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1. WO2011060272 - COMPOSITIONS, KITS, AND METHODS FOR THE DIAGNOSIS, PROGNOSIS, MONITORING, TREATMENT AND MODULATION OF POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS AND HYPOXIA ASSOCIATED ANGIOGENESIS DISORDERS USING GALECTIN-1

Publication Number WO/2011/060272
Publication Date 19.05.2011
International Application No. PCT/US2010/056547
International Filing Date 12.11.2010
IPC
C07K 16/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
G01N 33/577 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
577involving monoclonal antibodies
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US] (AllExceptUS)
  • THE BRIGHAM AND WOMEN' S HOSPITAL, INC. [US]/[US] (AllExceptUS)
  • CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) [AR]/[AR] (AllExceptUS)
  • FUNDACION SALES [AR]/[AR] (AllExceptUS)
  • SHIPP, Margaret, A. [US]/[US] (UsOnly)
  • OUYANG, Jing [CN]/[US] (UsOnly)
  • TAKEYAMA, Kunihiko [JP]/[JP] (UsOnly)
  • KUTOK, Jeffery L. [US]/[US] (UsOnly)
  • RODIG, Scott J. [US]/[US] (UsOnly)
  • RABINOVICH, Gabriel [AR]/[AR] (UsOnly)
  • RUSSO, Diego, Omar, Croci [AR]/[AR] (UsOnly)
  • SALATINO, Mariana [AR]/[AR] (UsOnly)
Inventors
  • SHIPP, Margaret, A.
  • OUYANG, Jing
  • TAKEYAMA, Kunihiko
  • KUTOK, Jeffery L.
  • RODIG, Scott J.
  • RABINOVICH, Gabriel
  • RUSSO, Diego, Omar, Croci
  • SALATINO, Mariana
Agents
  • SMITH, DeAnn, F.
Priority Data
61/261,12513.11.2009US
61/283,15930.11.2009US
61/335,77912.01.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS, KITS, AND METHODS FOR THE DIAGNOSIS, PROGNOSIS, MONITORING, TREATMENT AND MODULATION OF POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS AND HYPOXIA ASSOCIATED ANGIOGENESIS DISORDERS USING GALECTIN-1
(FR) COMPOSITIONS, KITS ET MÉTHODES UTILISÉS POUR LE DIAGNOSTIC, LE PRONOSTIC, LA SURVEILLANCE, LE TRAITEMENT ET LA MODULATION DES LYMPHOPROLIFÉRATIONS APRÈS GREFFE D'ORGANE ET DE L'HYPOXIE ASSOCIÉE À L'ANGIOGENÈSE AU MOYEN DE LA GALECTINE-1
Abstract
(EN) The present invention is based, in part, on the discovery that galectin-1 (Gall) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders. Accordingly, the invention relates to compositions, kits, and methods for diagnosing, prognosing, monitoring, treating and modulating viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.
(FR) Cette invention concerne notamment la découverte selon laquelle la galectine-1 (Gal1) joue un rôle dans les lymphoproliférations après greffe d'organe associées aux virus, par exemple les lymphoproliférations associées au VEB et l'hypoxie associée à l'angiogenèse. L'invention concerne des compositions, des kits et des méthodes de diagnostic, de pronostic, de surveillance, de traitement et de modulation des lymphoproliférations associées aux virus, notamment les lymphoproliférations associées au VEB et l'hypoxie associée à l'angiogenèse.
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