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1. WO2011059833 - DUAL-MODE RASTER POINT SCANNING/LIGHT SHEET ILLUMINATION MICROSCOPE

Publication Number WO/2011/059833
Publication Date 19.05.2011
International Application No. PCT/US2010/054809
International Filing Date 29.10.2010
IPC
G02B 21/06 2006.1
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
06Means for illuminating specimen
G02B 21/00 2006.1
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
G01N 21/64 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
CPC
G01N 2021/655
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
65Raman scattering
653Coherent methods [CARS]
655Stimulated Raman
G01N 21/6408
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6408with measurement of decay time, time resolved fluorescence
G01N 21/6428
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
G01N 21/6458
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6456Spatial resolved fluorescence measurements; Imaging
6458Fluorescence microscopy
G01N 21/6486
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
G02B 21/002
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
Applicants
  • CALIFORNIA INSTITUTE OF TECHNOLOGY [US]/[US] (AllExceptUS)
  • TRUONG, Thai, V. [US]/[US] (UsOnly)
  • CHOI, John, M. [US]/[US] (UsOnly)
  • FRASER, Scott, E. [US]/[US] (UsOnly)
  • SUPATTO, Willy [FR]/[FR] (UsOnly)
  • KOOS, David, S. [US]/[US] (UsOnly)
Inventors
  • TRUONG, Thai, V.
  • CHOI, John, M.
  • FRASER, Scott, E.
  • SUPATTO, Willy
  • KOOS, David, S.
Agents
  • PECK, John, W.
Priority Data
61/256,00529.10.2009US
61/256,01029.10.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DUAL-MODE RASTER POINT SCANNING/LIGHT SHEET ILLUMINATION MICROSCOPE
(FR) MICROSCOPE À ÉCLAIRAGE DOUBLE MODE PAR COUCHE LUMINEUSE/BALAYAGE POINT DE TRAME
Abstract
(EN)
An apparatus for and method of performing light sheet microscopy (LISH) and light scanning microscopy (RAPS) in a single device are provided. The dual-mode imaging microscope allows for the use of both LISH and RAPS in a single instrument. This dual-mode device will allow researchers to have access to both types of microscopy, allowing access to the widest possible selection of samples. In addition, the device will reduce the high costs and space requirements associated with owning two different microscopes (LISH and RAPS).
(FR)
L'invention concerne un appareil et un procédé de microscopie par couche lumineuse (microscopie LISH) et de microscopie par balayage lumineux (microscopie RAPS) dans un même dispositif. Un tel microscope d'imagerie double mode permet d'utiliser la microscopie LISH et RAPS dans un même instrument. Ce dispositif double mode permet aux chercheurs d'accéder aux deux types de microscopie, ouvrant l'accès à la sélection la plus large possible d'échantillons. De plus, ce dispositif réduit les coûts et les besoins d'espace élevés associés à l'utilisation de deux microscopes différents (microscopie LISH et RAPS).
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