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1. WO2011058111 - AMINOPURINE DERIVATIVES AS KINASE INHIBITORS

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Publication Number WO/2011/058111
Publication Date 19.05.2011
International Application No. PCT/EP2010/067307
International Filing Date 11.11.2010
IPC
C07D 473/16 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
02with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
16two nitrogen atoms
A61K 31/52 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 473/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
02with oxygen, sulfur or nitrogen atoms directly attached in positions 2 and 6
16two nitrogen atoms
Applicants
  • UCB PHARMA S.A. [BE]/[BE] (AllExceptUS)
  • ALLEN, Daniel, Rees [GB]/[GB] (UsOnly)
  • BÜRLI, Roland [CH]/[GB] (UsOnly)
  • HAUGHAN, Alan, Findlay [GB]/[GB] (UsOnly)
  • MATTEUCCI, Mizio [IT]/[GB] (UsOnly)
  • OWENS, Andrew, Pate [GB]/[GB] (UsOnly)
  • RAPHY, Gilles [GB]/[GB] (UsOnly)
  • SHARPE, Andrew [GB]/[GB] (UsOnly)
Inventors
  • ALLEN, Daniel, Rees
  • BÜRLI, Roland
  • HAUGHAN, Alan, Findlay
  • MATTEUCCI, Mizio
  • OWENS, Andrew, Pate
  • RAPHY, Gilles
  • SHARPE, Andrew
Agents
  • THOMPSON, John
Priority Data
0919821.912.11.2009GB
1012100.219.07.2010GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) AMINOPURINE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS D'AMINOPURINE EN TANT QU'INHIBITEURS DE KINASE
front page image
Abstract
(EN) A series of substituted 2-amino-9H-purin-6-yl derivatives, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
(FR) La présente invention concerne une série de dérivés de 2-amino-9H-purin-6-yle substitués, étant des inhibiteurs sélectifs d'enzymes kinase PI3, et qui sont en conséquence bénéfiques en médecine, par exemple dans le traitement d'affections inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.
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