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1. (WO2011058111) AMINOPURINE DERIVATIVES AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2011/058111 International Application No.: PCT/EP2010/067307
Publication Date: 19.05.2011 International Filing Date: 11.11.2010
IPC:
C07D 473/16 (2006.01) ,A61K 31/52 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
02
with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
16
two nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
ALLEN, Daniel, Rees [GB/GB]; GB (UsOnly)
BÜRLI, Roland [CH/GB]; GB (UsOnly)
HAUGHAN, Alan, Findlay [GB/GB]; GB (UsOnly)
MATTEUCCI, Mizio [IT/GB]; GB (UsOnly)
OWENS, Andrew, Pate [GB/GB]; GB (UsOnly)
RAPHY, Gilles [GB/GB]; GB (UsOnly)
SHARPE, Andrew [GB/GB]; GB (UsOnly)
UCB PHARMA S.A. [BE/BE]; 60, allée de la Recherche B-1070 Brussels, BE (AllExceptUS)
Inventors:
ALLEN, Daniel, Rees; GB
BÜRLI, Roland; GB
HAUGHAN, Alan, Findlay; GB
MATTEUCCI, Mizio; GB
OWENS, Andrew, Pate; GB
RAPHY, Gilles; GB
SHARPE, Andrew; GB
Agent:
THOMPSON, John; UCB Celltech 208 Bath Road Slough Berkshire SL1 3WE, GB
Priority Data:
0919821.912.11.2009GB
1012100.219.07.2010GB
Title (EN) AMINOPURINE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS D'AMINOPURINE EN TANT QU'INHIBITEURS DE KINASE
Abstract:
(EN) A series of substituted 2-amino-9H-purin-6-yl derivatives, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
(FR) La présente invention concerne une série de dérivés de 2-amino-9H-purin-6-yle substitués, étant des inhibiteurs sélectifs d'enzymes kinase PI3, et qui sont en conséquence bénéfiques en médecine, par exemple dans le traitement d'affections inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)