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1. (WO2011058109) FUSED BICYCLIC PYRROLE AND IMIDAZOLE DERIVATIVES AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/058109 International Application No.: PCT/EP2010/067305
Publication Date: 19.05.2011 International Filing Date: 11.11.2010
IPC:
C07D 487/04 (2006.01) ,A61K 31/53 (2006.01) ,A61K 31/5025 (2006.01) ,A61P 29/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 9/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
5025
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
Applicants:
ALLEN, Daniel, Rees [GB/GB]; GB (UsOnly)
BÜRLI, Roland [CH/GB]; GB (UsOnly)
HAUGHAN, Alan, Findlay [GB/GB]; GB (UsOnly)
MATTEUCCI, Mizio [IT/GB]; GB (UsOnly)
OWENS, Andrew, Pate [GB/GB]; GB (UsOnly)
RAPHY, Gilles [GB/GB]; GB (UsOnly)
SHARPE, Andrew [GB/GB]; GB (UsOnly)
UCB PHARMA S.A. [BE/BE]; 60 allée de la Recherche B-1070 Brussels, BE (AllExceptUS)
Inventors:
ALLEN, Daniel, Rees; GB
BÜRLI, Roland; GB
HAUGHAN, Alan, Findlay; GB
MATTEUCCI, Mizio; GB
OWENS, Andrew, Pate; GB
RAPHY, Gilles; GB
SHARPE, Andrew; GB
Agent:
THOMPSON, John; UCB Celltech 208 Bath Road Slough Berkshire SL1 3WE, GB
Priority Data:
0919825.012.11.2009GB
1012101.019.07.2010GB
Title (EN) FUSED BICYCLIC PYRROLE AND IMIDAZOLE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS DE PYRROLE ET D'IMIDAZOLE BICYCLIQUES CONDENSÉS EN TANT QU'INHIBITEURS DE KINASE
Abstract:
(EN) A series of substituted pyrrolo[2,1-ƒ][1,2,4]triazine and imidazo[2,1-ƒ]-[1,2,4]triazine derivatives, and fused pyridazine analogues thereof, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions (Formula (I)).
(FR) La présente invention concerne une série de dérivés de pyrrolo[2,1-ƒ][1,2,4]triazine et d'imidazo[2,1-ƒ]-[1,2,4]triazine substitués, et des analogues de pyridazine condensés de ceux-ci, étant des inhibiteurs sélectifs d'enzymes kinase PI3, et qui sont en conséquence bénéfiques en médecine, par exemple dans le traitement d'affections inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques (formule (I)).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)