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1. (WO2011051906) METHOD FOR NATIVE LIGATION OF POLYPEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/051906 International Application No.: PCT/IB2010/054897
Publication Date: 05.05.2011 International Filing Date: 28.10.2010
IPC:
C07K 1/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
02
in solution
Applicants: MHIDIA, Reda[MA/FR]; FR (UsOnly)
DHEUR, Julien[FR/FR]; FR (UsOnly)
OLLIVIER, Nathalie[FR/FR]; FR (UsOnly)
MELNYK, Oleg[FR/FR]; FR (UsOnly)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)[FR/FR]; 3 rue Michel Ange F-75794 PARIS Cedex 16, FR (AllExceptUS)
INSTITUT PASTEUR DE LILLE[FR/FR]; 1, rue du Pr. Calmette BP 245 F-59019 LILLE Cedex, FR (AllExceptUS)
Inventors: MHIDIA, Reda; FR
DHEUR, Julien; FR
OLLIVIER, Nathalie; FR
MELNYK, Oleg; FR
Agent: POCHART François,; Cabinet HIRSCH-POCHART & ASSOCIES 58 avenue Marceau F-75008 Paris, FR
Priority Data:
09 5763929.10.2009FR
Title (EN) METHOD FOR NATIVE LIGATION OF POLYPEPTIDES
(FR) PROCEDE DE LIGATION NATIVE DE POLYPEPTIDES
Abstract:
(EN) The invention mainly relates to a method for manufacturing a polypeptide with the formula: (III) X1-X"-X2, in which X1 and X2 are each a peptide fragment, and X" is an amino-acid residue comprising a thiol function, said method including at least one step of reacting a ligation between a polypeptide with the formula: (I) X1-N(CH2CH2SH)2 and a polypeptide with the formula: (II) H-X"-X2. The invention also relates to polypeptides with the formula (I) as well as to the method for obtaining same and to resin substrates suitable for obtaining same.
(FR) L'invention concerne principalement un procédé de fabrication d'un polypeptide de formule : (III) X1-X"-X2 X1 et X2 représentant chacun un fragment peptidique, et X" représentant un résidu d'acide aminé comportant une fonction thiol, ledit procédé comprenant au moins une étape de réaction de ligation entre un polypeptide de formule : (I) X1-N(CH2CH2SH)2 et un polypeptide de formule : (II) H-X"-X2. L'invention concerne également les polypeptides de formule (I) eux- mêmes et leur procédé d'obtention, ainsi que des supports de résine adaptés à leur obtention.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)