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1. WO2011038363 - BETA-DEFENSIN 2 GENETIC VARIATION PREDICTS H. PYLORI SUSCEPTIBILITY

Publication Number WO/2011/038363
Publication Date 31.03.2011
International Application No. PCT/US2010/050435
International Filing Date 27.09.2010
IPC
C12Q 1/68 2006.01
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68involving nucleic acids
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09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
CPC
C12Q 1/6883
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156Polymorphic or mutational markers
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2600Oligonucleotides characterized by their use
16Primer sets for multiplex assays
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • BEVINS, Charles L. [US]/[US] (UsOnly)
  • SOLNICK, Jay V. [US]/[US] (UsOnly)
  • HORNSBY, Michael J. [US]/[US] (UsOnly)
  • KAYS, Robert J. [US]/[US] (UsOnly)
Inventors
  • BEVINS, Charles L.
  • SOLNICK, Jay V.
  • HORNSBY, Michael J.
  • KAYS, Robert J.
Agents
  • WAHLSTEN, Jennifer L.
Priority Data
61/246,44928.09.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BETA-DEFENSIN 2 GENETIC VARIATION PREDICTS H. PYLORI SUSCEPTIBILITY
(FR) VARIATION GÉNÉTIQUE DE LA BÊTA-DÉFENSINE 2 POUR PRÉVOIR UNE PRÉDISPOSITION À UNE INFECTION À H. PYLORI
Abstract
(EN)
The present invention relates to correlating high gene copy number and/or the overexpression of β-defensin 2 ("BD2") with susceptibility to disease conditions resulting from, associated with or mediated by Helicobacter pylori infection, for example, susceptibility to peptic ulcer, non-ulcer dyspepsia, gastric cancer (e.g., gastric adenocarcinoma), and mucosa associated lymphoid tissue (MALT) lymphoma.
(FR)
La présente invention concerne la corrélation d'un nombre de copies d'un gène élevé et/ou la surexpression de la β-défensine 2 ("BD2") à une prédisposition à des états pathologiques provoqués par, associés à et dont la médiation est assurée par une infection à Helicobacter pylori, par exemple, la prédisposition à l'ulcère gastroduodénal, la dyspepsie non ulcéreuse, le cancer gastrique (par exemple, adénocarcinome gastrique), et le lymphome du tissu lymphoïde associé aux muqueuses (MALT).
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