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1. WO2011038043 - OPTICAL IMAGING CONTRAST AGENTS AND USES THEROF

Publication Number WO/2011/038043
Publication Date 31.03.2011
International Application No. PCT/US2010/049886
International Filing Date 22.09.2010
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
CPC
A61B 8/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
06Measuring blood flow
A61B 8/065
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
06Measuring blood flow
065to determine blood output from the heart
A61B 8/0883
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
08Detecting organic movements or changes, e.g. tumours, cysts, swellings
0883for diagnosis of the heart
A61B 8/0891
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
08Detecting organic movements or changes, e.g. tumours, cysts, swellings
0891for diagnosis of blood vessels
A61B 8/481
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
48Diagnostic techniques
481involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
A61B 8/5223
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
52Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
5215involving processing of medical diagnostic data
5223for extracting a diagnostic or physiological parameter from medical diagnostic data
Applicants
  • TARGESON, INC. [US]/[US] (AllExceptUS)
  • RYCHAK, Joshua J. [US]/[US] (UsOnly)
Inventors
  • RYCHAK, Joshua J.
Agents
  • HELMBACHER, Kevin S.
Priority Data
61/277,19222.09.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OPTICAL IMAGING CONTRAST AGENTS AND USES THEROF
(FR) AGENTS DE CONTRASTE D'IMAGERIE OPTIQUE ET LEURS UTILISATIONS
Abstract
(EN)
The invention relates to microbubble contrast agent compositions comprising a gas core encapsulated by a monolayer shell, said shell comprising a first surfactant, a second surfactant having a higher water solubility than said first surfactant, an anchor molecule attached to said shell at the gas-shell interface and an optically-active probe, said probe being detectable by fluorescence, near-infrared, bioluminescence, or other optical imaging methods. Uses of the described compositions for imaging and therapeutic applications are contemplated.
(FR)
La présente invention a pour objet des compositions d'agent de contraste à base de microbulles comprenant un noyau gazeux encapsulé par une coque monocouche. Cette coque comprend un premier agent tensioactif, un second agent tensioactif ayant une solubilité dans l'eau supérieure au premier agent tensioactif, une molécule d'ancrage fixée sur la coque au niveau de l'interface gaz-coque et une sonde optiquement active détectable par fluorescence, proche infrarouge, bioluminescence, ou d'autres procédés d'imagerie optique. La présente invention concerne également les utilisations des compositions décrites pour des applications d'imagerie et thérapeutiques.
Also published as
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