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1. (WO2011036280) BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/036280 International Application No.: PCT/EP2010/064208
Publication Date: 31.03.2011 International Filing Date: 27.09.2010
Chapter 2 Demand Filed: 03.06.2011
IPC:
C07D 498/04 (2006.01) ,C07D 498/14 (2006.01) ,C07D 519/00 (2006.01) ,A61K 31/4162 (2006.01) ,A61K 31/4188 (2006.01) ,A61K 31/4196 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
4162
condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4188
condensed with heterocyclic ring systems, e.g. biotin, sorbinil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
BLAQUIERE, Nicole [CA/US]; US (UsOnly)
DO, Steven [US/US]; US (UsOnly)
DUDLEY, Danette [US/US]; US (UsOnly)
FOLKES, Adrian J. [GB/GB]; GB (UsOnly)
HEALD, Robert [GB/GB]; GB (UsOnly)
HEFFRON, Timothy [US/US]; US (UsOnly)
JONES, Mark [GB/GB]; GB (UsOnly)
KOLESNIKOV, Aleksandr [US/US]; US (UsOnly)
NDUBAKU, Chudi [US/US]; US (UsOnly)
OLIVERO, Alan G. [US/US]; US (UsOnly)
PRICE, Stephen [GB/GB]; GB (UsOnly)
STABEN, Steven [US/US]; US (UsOnly)
WANG, Lan [CA/US]; US (UsOnly)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
Inventors:
BLAQUIERE, Nicole; US
DO, Steven; US
DUDLEY, Danette; US
FOLKES, Adrian J.; GB
HEALD, Robert; GB
HEFFRON, Timothy; US
JONES, Mark; GB
KOLESNIKOV, Aleksandr; US
NDUBAKU, Chudi; US
OLIVERO, Alan G.; US
PRICE, Stephen; GB
STABEN, Steven; US
WANG, Lan; US
Agent:
SAUER, Frank; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
61/246,38128.09.2009US
61/330,68503.05.2010US
Title (EN) BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
(FR) COMPOSÉS DE BENZOXAZÉPINE INHIBITEURS DE PI3K ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The invention relates to benzoxazepin compounds of Formula (I) including stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring which compounds have anti-cancer activity, and more specifically, inhibit PI3 kinase activity.
(FR) L'invention porte sur des composés de benzoxazépine de formule (I) y compris les stéréoisomères, isomères géométriques, tautomères ou sels pharmaceutiquement acceptables de ceux-ci, dans laquelle formule : Z1 représente CR1 ou N; Z2 représente CR2 ou N; Z3 représente CR3 ou N; Z4 représente CR4 ou N; et B représente un noyau pyrazolyle, imidazolyle ou triazolyle, lesquels composés ont une activité anticancéreuse et, plus spécifiquement, inhibent l'activité de la PI3-kinase.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)