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1. WO2011035261 - RECONSTITUTABLE REVERSE THERMAL GELLING POLYMERS

Publication Number WO/2011/035261
Publication Date 24.03.2011
International Application No. PCT/US2010/049526
International Filing Date 20.09.2010
IPC
C08G 63/08 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
02Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds
06derived from hydroxy carboxylic acids
08Lactones or lactides
CPC
A61K 47/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 9/0024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
A61K 9/5153
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
513Organic macromolecular compounds; Dendrimers
5146obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
5153Polyesters, e.g. poly(lactide-co-glycolide)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C08G 2261/126
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
2261Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
10Definition of the polymer structure
12Copolymers
126block
C08G 63/08
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
63Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
06derived from hydroxycarboxylic acids
08Lactones or lactides
Applicants
  • PROTHERICS MEDICINES DEVELOPMENT LIMITED [GB]/[GB] (AllExceptUS)
  • FOWERS, Kirk, D. [US]/[US] (UsOnly)
  • RATHI, Ramesh [US]/[US] (UsOnly)
  • PIAO, Ai-Zhi [CN]/[US] (UsOnly)
Inventors
  • FOWERS, Kirk, D.
  • RATHI, Ramesh
  • PIAO, Ai-Zhi
Agents
  • SCHULMAN, Robert, M.
Priority Data
12/562,65318.09.2009US
61/275,71718.09.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RECONSTITUTABLE REVERSE THERMAL GELLING POLYMERS
(FR) POLYMÈRES RECONSTITUABLES À GÉLIFICATION THERMIQUE INVERSÉE
Abstract
(EN)
Biodegradable and bioabsorbable block copolymers, which can be in the form of solid powder or powder wax compositions that can be easily reconstituted into an aqueous polymer solution and exhibit reverse thermal gellation properties upon exposure to elevated temperatures, are provided. Methods of making using these copolymers are also provided.
(FR)
La présente invention concerne des copolymères séquencés biodégradables et bioabsorbables, pouvant se présenter sous la forme de compositions constituées d'une poudre solide ou d'une poudre cireuse, pouvant être facilement reconstituées pour donner une solution polymère aqueuse, présentant des propriétés de gélification thermique inversée suite à son exposition à des températures élevées. L'invention concerne également des procédés de fabrication et d'utilisation desdits copolymères.
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