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1. WO2011035065 - MONOCONJUGATED CHITOSANS AS DELIVERY AGENTS FOR SMALL INTERFERING NUCLEIC ACIDS

Publication Number WO/2011/035065
Publication Date 24.03.2011
International Application No. PCT/US2010/049179
International Filing Date 16.09.2010
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 47/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
549Sugars, nucleosides, nucleotides or nucleic acids
A61K 47/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Applicants
  • NEKTAR THERAPEUTICS [US]/[US] (AllExceptUS)
  • MCMANUS, Samuel, P. [US]/[US] (UsOnly)
  • KOZLOWSKI, Antoni [US]/[US] (UsOnly)
  • YOUSO, Patrick, D. [US]/[US] (UsOnly)
Inventors
  • MCMANUS, Samuel, P.
  • KOZLOWSKI, Antoni
  • YOUSO, Patrick, D.
Agents
  • WILSON, Mark, A.
Priority Data
61/243,51617.09.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONOCONJUGATED CHITOSANS AS DELIVERY AGENTS FOR SMALL INTERFERING NUCLEIC ACIDS
(FR) CHITOSANES MONOCONJUGUÉS EN TANT QU'AGENTS DE DISTRIBUTION POUR DE PETITS ACIDES NUCLÉIQUES INTERFÉRENTS
Abstract
(EN)
Conjugates are provided, an exemplary conjugating having a single water-soluble, non-peptidic polymer, such as a poly( ethylene oxide), attached to a chitosan. Complexes of small interfering nucleic acids formed with such conjugates as well as small interfering nucleic acids attached to such conjugates are also provided. Related methods, intermediates, and compositions are also provided.
(FR)
L'invention concerne des conjugués, un conjugué à titre d'exemple ayant un unique polymère non peptidique soluble dans l'eau tel qu'un poly(oxyde d'éthylène) attaché à un chitosan. L'invention concerne également des complexes de petits acides nucléiques interférents formés avec de tels conjugués ainsi que de petits acides nucléiques interférents attachés à de tels conjugués. L'invention concerne également des procédés, intermédiaires et compositions apparentés.
Also published as
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