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1. WO2011034465 - A PHARMACEUTICAL COMPOSITION FOR PERORAL ADMINISTRATION OF DIINDOLYLMETHANE

Publication Number WO/2011/034465
Publication Date 24.03.2011
International Application No. PCT/RU2010/000487
International Filing Date 07.09.2010
IPC
A61K 31/404 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
A61K 9/107 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
A61K 47/30 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
CPC
A61K 31/404
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61K 47/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 9/2031
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
2031obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
Applicants
  • ЗАКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО «ВЕЛЕС ФАРМА» ZAKRYTOE AKTSIONERNOE OBSCHESTVO "VELES FARMA" [RU]/[RU] (AllExceptUS)
  • КИСЕЛЕВ, Всеволод Иванович KISELEV, Vsevolod Ivanovich [RU]/[RU] (UsOnly)
  • ВАСИЛЬЕВА, Ирина Геннадиевна VASSILIEVA, Irina Gennadievna [RU]/[RU] (UsOnly)
Inventors
  • КИСЕЛЕВ, Всеволод Иванович KISELEV, Vsevolod Ivanovich
  • ВАСИЛЬЕВА, Ирина Геннадиевна VASSILIEVA, Irina Gennadievna
Agents
  • ПИЛИШКИНА, Людмила Станиславовна PILISHKINA, Lyudmila Stanislavovna
Priority Data
200913487218.09.2009RU
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) A PHARMACEUTICAL COMPOSITION FOR PERORAL ADMINISTRATION OF DIINDOLYLMETHANE
(FR) COMPOSITION PHARMACEUTIQUE DESTINÉ À L'ADMINISTRATION ORALE DE DIINDOLYLMÉTHANE
(RU) ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ПЕРОРАЛЬНОЙ ДОСТАВКИ ДИИНДОЛИЛМЕТАНА
Abstract
(EN)
The invention relates to the field of pharmaceuticals. The invention describes block copolymer pharmaceutical compositions containing 3,3'-diindolylmethane (DIM). A pharmaceutical composition for peroral administration comprises 3,3'-diindolylmethane as active ingredient and a target additive, wherein said composition comprises, as target additive, a block copolymer of oxyethylene and oxypropylene, in which the hydrophobic block content is less than 50% by mass, and the molecular mass of the hydrophilic block is 2250 Da or more, given a ratio of active ingredient to the selected block copolymer of 10:1-2:1. The compositions improve the absorption of the active compound in the bloodstream when said active compound is administered perorally.
(FR)
L'invention concerne le domaine pharmaceutique et décrie des compositions pharmaceutiques copolymères bloc contenant le 3,3'-diindolylméthane (DIM). La composition pharmaceutique destinée à l'administration orale comprend le 3,3'-diindolylméthane en tant qu'agent actif et un additif spécifique qui est constitué d'un polymère bloc d'oxyéthylène et d'oxypropylène dans lequel la part du bloc hydrofuge inférieure ou égale à 50 %, le poids moléculaire du bloc hydrophile étant de 2250 Da ou plus, le rapport de l'agent actif et du copolymère bloc choisi étant de 10 :1-2 :1. La composition permet d'améliorer l'absorption de l'agent actif dans le flux sanguin lors de son administration orale.
(RU)
Изобретение относится к области фармации. Описываются блок-сополимерные фармацевтические композиции с 3,3'- дииндолилметаном (DIM). Фармацевтическая композиция для перорального введения содержит 3,3'-дииндoлилмeтaн в качестве активного компонента и целевую добавку, причем она содержит в качестве целевой добавки блок-сополимер оксиэтилена и оксипропилена, в котором содержание гидрофобного блока составляет менее 50 мacc.%, а молекулярная масса гидрофильного блока составляет 2250 Да и более, при соотношении активного компонента и выбранного блок-сополимера 10:1-2:1. Композиции улучшают абсорбцию активного соединения в кровоток при его пероральной доставке.
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