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1. (WO2011033265) PHARMACEUTICAL COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/033265 International Application No.: PCT/GB2010/001746
Publication Date: 24.03.2011 International Filing Date: 17.09.2010
IPC:
C07D 311/26 (2006.01) ,C07D 407/04 (2006.01) ,C07D 491/04 (2006.01) ,A61K 31/353 (2006.01) ,A61K 31/4155 (2006.01) ,A61K 31/4162 (2006.01) ,A61K 31/436 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
04
Benzo [b] pyrans, not hydrogenated in the carbocyclic ring
22
with oxygen or sulfur atoms directly attached in position 4
26
with aromatic rings attached in position 2 or 3
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
407
Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
4155
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
4162
condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
436
the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
BELL, Mark Peter [GB/GB]; GB (UsOnly)
O'DOWD, Colin Roderick [GB/GB]; GB (UsOnly)
ZHANG, Lixin [GB/GB]; GB (UsOnly)
TREVITT, Graham Peter [GB/GB]; GB (UsOnly)
HARRISON, Timothy [GB/GB]; GB (UsOnly)
BHATTACHARYYA, Sumita [SE/GB]; GB (UsOnly)
ROUNTREE, James Samuel Shane [GB/GB]; GB (UsOnly)
BURKAMP, Frank [DE/GB]; GB (UsOnly)
PRICE, Stephen [GB/GB]; GB (UsOnly)
MACLEOD, Calum [GB/GB]; GB (UsOnly)
ELLIOTT, Richard Leonard [GB/GB]; GB (UsOnly)
SMITH, Phillip [GB/GB]; GB (UsOnly)
BLENCH, Toby Jonathan [GB/GB]; GB (UsOnly)
DYKE, Hazel Joan [GB/GB]; GB (UsOnly)
ALMAC DISCOVERY LIMITED [GB/GB]; Almac House 20 Seagoe Industrial Estate Craigavon BT63 5QD Northern Ireland, GB (AllExceptUS)
Inventors:
BELL, Mark Peter; GB
O'DOWD, Colin Roderick; GB
ZHANG, Lixin; GB
TREVITT, Graham Peter; GB
HARRISON, Timothy; GB
BHATTACHARYYA, Sumita; GB
ROUNTREE, James Samuel Shane; GB
BURKAMP, Frank; GB
PRICE, Stephen; GB
MACLEOD, Calum; GB
ELLIOTT, Richard Leonard; GB
SMITH, Phillip; GB
BLENCH, Toby Jonathan; GB
DYKE, Hazel Joan; GB
Agent:
WHITE, Nina Louise; Boult Wade Tennant Verulam Garden 70 Gray's Inn Road London WC1X 8BT, GB
Priority Data:
0916458.318.09.2009GB
1005734.706.04.2010GB
Title (EN) PHARMACEUTICAL COMPOUNDS
(FR) COMPOSÉS PHARMACEUTIQUES
Abstract:
(EN) The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.
(FR) L'invention concerne une série de composés qui ont une activité particulière comme inhibiteurs de la sérine-thréonine kinase AKT. L'invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que des procédés pour traiter le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)