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1. WO2011033265 - PHARMACEUTICAL COMPOUNDS

Publication Number WO/2011/033265
Publication Date 24.03.2011
International Application No. PCT/GB2010/001746
International Filing Date 17.09.2010
IPC
C07D 311/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
04Benzo pyrans, not hydrogenated in the carbocyclic ring
22with oxygen or sulfur atoms directly attached in position 4
26with aromatic rings attached in position 2 or 3
C07D 407/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 491/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/353 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/4155 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
4155not condensed and containing further heterocyclic rings
A61K 31/4162 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
4162condensed with heterocyclic ring systems
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 311/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
22with oxygen or sulfur atoms directly attached in position 4
26with aromatic rings attached in position 2 or 3
C07D 407/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 491/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • ALMAC DISCOVERY LIMITED [GB]/[GB] (AllExceptUS)
  • BELL, Mark Peter [GB]/[GB] (UsOnly)
  • O'DOWD, Colin Roderick [GB]/[GB] (UsOnly)
  • ZHANG, Lixin [GB]/[GB] (UsOnly)
  • TREVITT, Graham Peter [GB]/[GB] (UsOnly)
  • HARRISON, Timothy [GB]/[GB] (UsOnly)
  • BHATTACHARYYA, Sumita [SE]/[GB] (UsOnly)
  • ROUNTREE, James Samuel Shane [GB]/[GB] (UsOnly)
  • BURKAMP, Frank [DE]/[GB] (UsOnly)
  • PRICE, Stephen [GB]/[GB] (UsOnly)
  • MACLEOD, Calum [GB]/[GB] (UsOnly)
  • ELLIOTT, Richard Leonard [GB]/[GB] (UsOnly)
  • SMITH, Phillip [GB]/[GB] (UsOnly)
  • BLENCH, Toby Jonathan [GB]/[GB] (UsOnly)
  • DYKE, Hazel Joan [GB]/[GB] (UsOnly)
Inventors
  • BELL, Mark Peter
  • O'DOWD, Colin Roderick
  • ZHANG, Lixin
  • TREVITT, Graham Peter
  • HARRISON, Timothy
  • BHATTACHARYYA, Sumita
  • ROUNTREE, James Samuel Shane
  • BURKAMP, Frank
  • PRICE, Stephen
  • MACLEOD, Calum
  • ELLIOTT, Richard Leonard
  • SMITH, Phillip
  • BLENCH, Toby Jonathan
  • DYKE, Hazel Joan
Agents
  • WHITE, Nina Louise
Priority Data
0916458.318.09.2009GB
1005734.706.04.2010GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PHARMACEUTICAL COMPOUNDS
(FR) COMPOSÉS PHARMACEUTIQUES
Abstract
(EN) The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.
(FR) L'invention concerne une série de composés qui ont une activité particulière comme inhibiteurs de la sérine-thréonine kinase AKT. L'invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que des procédés pour traiter le cancer.
Related patent documents
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