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1. WO2011031327 - NICOTINE HAPTENS, IMMUNOCONJUGATES AND THEIR USES

Publication Number WO/2011/031327
Publication Date 17.03.2011
International Application No. PCT/US2010/002489
International Filing Date 14.09.2010
IPC
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61K 31/4439 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 25/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
34Tobacco-abuse
CPC
A61K 31/4439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 25/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
34Tobacco-abuse
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • THE SCRIPPS RESEARCH INSTITUTE [US]/[US] (AllExceptUS)
  • JANDA, Kim, D. [US]/[US] (UsOnly)
Inventors
  • JANDA, Kim, D.
Agents
  • FITTING, Thomas
Priority Data
61/276,67914.09.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NICOTINE HAPTENS, IMMUNOCONJUGATES AND THEIR USES
(FR) HAPTÈNES NICOTINIQUES, IMMUNO-CONJUGUÉS ET LEURS UTILISATIONS
Abstract
(EN)
The present invention provides novel nicotine hapten compounds and nitocine immunoconjugates which can be used for in vivo production of antibodies that specifically bind to nicotine. The invention also provides methods of using vaccines comprising the nicotine immunoconjugates in active or passive immunization protocols. The compositions and methods of the invention are useful for prevention and treatment of nicotine addiction.
(FR)
La présente invention concerne de nouveaux composés d'haptènes nicotiniques et des immuno-conjugués nicotiniques pouvant être utilisés pour une production in vivo d'anticorps s'attachant spécifiquement à la nicotine. L'invention concerne également des procédés d'utilisation de vaccins comprenant les immuno-conjugués nicotiniques dans des protocoles d'immunisation active ou passive. Les compositions et les procédés de l'invention sont utiles pour la prévention et le traitement de la dépendance à la nicotine.
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