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1. WO2011030116 - USE OF STEROID COMPOUNDS FOR INFLAMMATORY AND AUTOIMMUNE DISORDERS

Publication Number WO/2011/030116
Publication Date 17.03.2011
International Application No. PCT/GB2010/001727
International Filing Date 13.09.2010
IPC
A61K 31/56 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A61K 31/575 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61P 11/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 21/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
04for myasthenia gravis
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 2121/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2121Preparations for use in therapy
A61K 31/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
A61K 31/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • BIONATURE E.A. LTD. [CY]/[CY] (AllExceptUS)
  • TOWLER, Philip, Dean [GB]/[GB] (MG)
  • PANOUTSAKOPOULOU, Vasiliki [GR]/[GR] (UsOnly)
  • ANGELAKOPOULOU, Maria [GR]/[GR] (UsOnly)
  • CALOGEROPOULOU, Theodora [GR]/[GR] (UsOnly)
  • GRAVANIS, Achilleas [GR]/[GR] (UsOnly)
  • LAZARIDIS, Lakovos [GR]/[GR] (UsOnly)
  • NEOPHYTOU, Constantinos [CY]/[CY] (UsOnly)
Inventors
  • PANOUTSAKOPOULOU, Vasiliki
  • ANGELAKOPOULOU, Maria
  • CALOGEROPOULOU, Theodora
  • GRAVANIS, Achilleas
  • LAZARIDIS, Lakovos
  • NEOPHYTOU, Constantinos
Agents
  • DEHNS
Priority Data
0916020.111.09.2009GB
1009342.503.06.2010GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF STEROID COMPOUNDS FOR INFLAMMATORY AND AUTOIMMUNE DISORDERS
(FR) UTILISATION DE COMPOSÉS STÉROÏDIENS POUR TROUBLES INFLAMMATOIRES ET AUTO-IMMUNS
Abstract
(EN)
This invention pertains to the use of steroid compounds including spirosteroid analogues in treating, preventing or ameliorating the symptoms of inflammatory conditions. The steroid compounds are useful for treating a range of inflammatory conditions, including, but not limited to asthma, lung inflammation, retinal inflammatory conditions, autoimmune diseases such as rheumatoid arthritis, diabetes type I, systemic lupus erythematosus, ulcerative colitis and inflammatory bowel diseases and myopathies, as well as multiple sclerosis. The active compounds are represented by Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, B, X, Y and Z are defined in the description of the invention.
(FR)
La présente invention concerne l'utilisation de composés stéroïdiens comprenant des analogues de spirostéroïde dans le traitement, la prévention ou l'amélioration des symptômes d'états inflammatoires. Lesdits composés stéroïdiens sont utiles dans le traitement de toute un éventail d'états inflammatoires, comprenant, sans caractère limitatif, l'asthme, l'inflammation pulmonaire, les états inflammatoires de la rétine, les maladies auto-immunes telles que la polyarthrite rhumatoïde, le diabète de type I, le lupus érythémateux systémique, la rectocolite hémorragique et les affections intestinales inflammatoires et les myopathies, ainsi que la sclérose en plaques. Les composés actifs sont représentés par la formule (I) : dans laquelle R1, R2, R3, R4, R5, R6, R7, A, B, X, Y et Z sont définis dans la description de l'invention.
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