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1. (WO2011025927) COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2011/025927 International Application No.: PCT/US2010/046930
Publication Date: 03.03.2011 International Filing Date: 27.08.2010
IPC:
C07D 401/14 (2006.01) ,C07D 403/04 (2006.01) ,A61K 31/506 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
IRM LLC [US/US]; 131 Front Street P.O Box HM 2899 Hamilton, HM LX, BM (AllExceptUS)
NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AllExceptUS)
HUANG, Shenlin [CN/US]; US (UsOnly)
JIN, Xianming [US/US]; US (UsOnly)
LIU, Zuosheng [CN/US]; US (UsOnly)
POON, Daniel [US/US]; US (UsOnly)
TELLEW, John E. [US/US]; US (UsOnly)
WAN, Yongqin [US/US]; US (UsOnly)
WANG, Xing [CN/US]; US (UsOnly)
XIE, Yongping [US/US]; US (UsOnly)
Inventors:
HUANG, Shenlin; US
JIN, Xianming; US
LIU, Zuosheng; US
POON, Daniel; US
TELLEW, John E.; US
WAN, Yongqin; US
WANG, Xing; US
XIE, Yongping; US
Agent:
REID, Scott; Genomics Institute of the Novartis Research Foundation 10675 John Jay Hopkins Drive San Diego, California 92121, US
Priority Data:
61/238,07328.08.2009US
61/313,03911.03.2010US
Title (EN) COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
(FR) COMPOSÉS ET COMPOSITIONS EN TANT QU'INHIBITEURS DE PROTÉINE KINASE
Abstract:
(EN) The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
(FR) L'invention porte sur une nouvelle classe de composés de la formule 1, sur des compositions pharmaceutiques comportant de tels composés et sur des procédés d'utilisation de tels composés pour traiter ou prévenir des maladies ou des troubles associés à une activité kinase anormale ou dérégulée, en particulier des maladies ou des troubles qui entraînent une activation anormale de B-Raf.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
RSP-2014/0430UAa201203042SG178351IL218084EP2470526DOP2012000051
JP2013503186CN102725283CA2771775EA201200373EP2727918ES2492499
KR1020120062839TN2012000081NZ598924DK2470526AU2010286569VN30470
ID2012/03594TH140028IN2469/DELNP/2012