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1. (WO2011023773) COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2011/023773 International Application No.: PCT/EP2010/062495
Publication Date: 03.03.2011 International Filing Date: 26.08.2010
IPC:
C07D 403/04 (2006.01) ,A61K 31/506 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AllExceptUS)
COSTALES, Abran Q. [US/US]; US (UsOnly)
HUANG, Shenlin [CN/US]; US (UsOnly)
JIN, Jeff (Xianming) [US/US]; US (UsOnly)
LIU, Zuosheng [CN/US]; US (UsOnly)
PECCHI, Sabina [IT/US]; US (UsOnly)
POON, Daniel [US/US]; US (UsOnly)
TELLEW, John [US/US]; US (UsOnly)
ZHANG, Qiong [CN/US]; US (UsOnly)
Inventors:
COSTALES, Abran Q.; US
HUANG, Shenlin; US
JIN, Jeff (Xianming); US
LIU, Zuosheng; US
PECCHI, Sabina; US
POON, Daniel; US
TELLEW, John; US
ZHANG, Qiong; US
Agent:
DYER, James; Novartis Pharma Ag Patent Department CH-4002 Basel, CH
Priority Data:
61/238,08328.08.2009US
61/313,06111.03.2010US
Title (EN) COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
(FR) COMPOSÉS ET COMPOSITIONS INHIBITEURS DE PROTÉINES KINASES
Abstract:
(EN) The present invention provides compounds of Formula (I) or (II) wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
(FR) Cette invention concerne des composés de Formule (I) ou (II) ; R1, R1b, R2, R3, R4, R5, R6 et R7 dans ces Formules étant tels que définis dans la présente. Les composés de Formule (I) ou (II) et les compositions pharmaceutiques les contenant sont utiles pour traiter les maladies associées à B-Raf.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2470528JP2013503139CN102596937CA2771673EA201200323ES2527176
KR1020120092577AU2010288455BR112012004448IN869/DELNP/2012