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1. WO2011023734 - PROCESS FOR THE PRECIPITATION OF INHALABLE PHARMACEUTICAL AGENTS IN THE PROPELLANT

Publication Number WO/2011/023734
Publication Date 03.03.2011
International Application No. PCT/EP2010/062430
International Filing Date 26.08.2010
IPC
A61K 9/72 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
72for smoking or inhaling
A61K 31/57 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
CPC
A61K 31/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
A61K 9/008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
008comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • ROBERTSON, John [GB]/[GB] (UsOnly)
  • VALDER, Christopher, Edmund [GB]/[GB] (UsOnly)
Inventors
  • ROBERTSON, John
  • VALDER, Christopher, Edmund
Agents
  • WALKER, Ralph, Francis
Priority Data
0915106.928.08.2009GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PRECIPITATION OF INHALABLE PHARMACEUTICAL AGENTS IN THE PROPELLANT
(FR) PROCÉDÉ POUR LA PRÉCIPITATION D'AGENTS PHARMACEUTIQUES INHALABLES DANS LE GAZ PROPULSEUR
Abstract
(EN)
A process for providing a dispersion of a pharmaceutical product in a liquefied gas propellant in a metered dose inhaler comprising preparing a supercritical solution of the pharmaceutical product dissolved in the propellant in a supercritical fluid state then reducing the temperature and pressure of the supercritical solution to respectively below Tc and below pc to precipitate the pharmaceutical product and provide a dispersion of the pharmaceutical product in the liquefied propellant; then charging the dispersion to the canister of an MDI.
(FR)
L'invention concerne un procédé pour obtenir une dispersion d'un produit pharmaceutique dans un gaz propulseur liquéfié dans un inhalateur-doseur, comprenant la préparation d'une solution supercritique du produit pharmaceutique dissous dans le propulseur à l'état de fluide supercritique, puis la réduction de la température et de la pression de la solution supercritique respectivement au-dessous de Tc et au-dessous de pc pour précipiter le produit pharmaceutique et obtenir une dispersion du produit pharmaceutique dans le propulseur liquéfié; puis le chargement de la dispersion dans la cartouche d'un inhalateur-doseur.
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