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1. (WO2011022670) IN VIVO SCREENING ASSAYS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/022670    International Application No.:    PCT/US2010/046196
Publication Date: 24.02.2011 International Filing Date: 20.08.2010
IPC:
A61K 49/00 (2006.01)
Applicants: GILEAD BIOLOGICS, INC. [US/US]; 333 Lakeside Drive Foster City, CA 94404 (US) (For All Designated States Except US).
MARSHALL, Derek [AU/US]; (US) (For US Only).
SMITH, Victoria [AU/US]; (US) (For US Only)
Inventors: MARSHALL, Derek; (US).
SMITH, Victoria; (US)
Agent: MILLS, Amy, A.; Morrison & Foerster LLP 12531 High Bluff Drive Suite 100 San Diego, CA 92130 (US)
Priority Data:
61/235,846 21.08.2009 US
Title (EN) IN VIVO SCREENING ASSAYS
(FR) ESSAIS DE CRIBLAGE IN VIVO
Abstract: front page image
(EN)Disclosed herein are methods for identifying inhibitors of LOXL2 activity using in vivo assays. The assays include, for example, CCL4-induced liver fibrosis, bleomycin-induced lung fibrosis, collagen-induced arthritis, tumor growth following surgical orthotopic implantation of cultured tumor cells, metastasis following intracardiac injection of cultured tumor cells, tumor xenograft models, and vasculogenesis and/or angiogenesis following implantation of exogenous basement membrane.
(FR)La présente invention a pour objet des méthodes d'identification d'inhibiteurs de l'activité de LOXL2 au moyen d'essais in vivo. Les essais comprennent, par exemple, la fibrose hépatique induite par le CCl4, la fibrose pulmonaire induite par la bléomycine, l'arthrite induite par le collagène, la croissance tumorale consécutive à une implantation orthotopique chirurgicale de cellules tumorales cultivées, la métastase consécutive à une injection intracardiaque de cellules tumorales cultivées, les modèles de xénogreffe de tumeur, et la vasculogenèse et/ou l'angiogenèse consécutives à l'implantation d'une membrane basale exogène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)