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1. (WO2011022460) NOVEL CATIONIC LIPIDS WITH VARIOUS HEAD GROUPS FOR OLIGONUCLEOTIDE DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/022460    International Application No.:    PCT/US2010/045854
Publication Date: 24.02.2011 International Filing Date: 18.08.2010
IPC:
C07C 229/00 (2006.01), A61K 9/127 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
CAMERON, Mark [GB/US]; (US) (For US Only).
DAVIS, Jennifer, R. [US/US]; (US) (For US Only).
GEISER, Andrea, R. [US/US]; (US) (For US Only).
STANTON, Matthew, G. [US/US]; (US) (For US Only).
TELYATNIKOV, Vladislav, V. [UA/US]; (US) (For US Only).
TIAN, Lu [US/US]; (US) (For US Only).
WANG, Weimin [US/US]; (US) (For US Only)
Inventors: CAMERON, Mark; (US).
DAVIS, Jennifer, R.; (US).
GEISER, Andrea, R.; (US).
STANTON, Matthew, G.; (US).
TELYATNIKOV, Vladislav, V.; (US).
TIAN, Lu; (US).
WANG, Weimin; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US)
Priority Data:
61/235,476 20.08.2009 US
61/345,754 18.05.2010 US
Title (EN) NOVEL CATIONIC LIPIDS WITH VARIOUS HEAD GROUPS FOR OLIGONUCLEOTIDE DELIVERY
(FR) NOUVEAUX LIPIDES CATIONIQUES AVEC DIFFÉRENTS GROUPES DE TÊTE POUR DÉLIVRANCE D'OLIGONUCLÉOTIDE
Abstract: front page image
(EN)The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.
(FR)La présente invention concerne de nouveaux lipides cationiques qui peuvent être utilisés en combinaison avec d'autres composants lipidiques tels que le cholestérol et des PEG-lipides pour former des nanoparticules de lipides avec des ARNsi, afin de faciliter l'absorption cellulaire et l'échappement des endosomes, et pour inactiver un ARNm cible in vitro et in vivo.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)