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Machine translation
1. (WO2011022213) AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/022213    International Application No.:    PCT/US2010/044482
Publication Date: 24.02.2011 International Filing Date: 05.08.2010
IPC:
C07D 471/00 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
BRESLIN, Michael, J. [US/US]; (US) (For US Only).
COLEMAN, Paul, J. [US/US]; (US) (For US Only).
COX, Christopher, D. [US/US]; (US) (For US Only).
RAHEEM, Izzat, T. [US/US]; (US) (For US Only).
SCHREIER, John, D. [US/US]; (US) (For US Only)
Inventors: BRESLIN, Michael, J.; (US).
COLEMAN, Paul, J.; (US).
COX, Christopher, D.; (US).
RAHEEM, Izzat, T.; (US).
SCHREIER, John, D.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
61/234,427 17.08.2009 US
Title (EN) AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS
(FR) INHIBITEURS DE PDE10 D'AMINO-TÉTRAHYDRO-PYRIDOPYRIMIDINE
Abstract: front page image
(EN)The present invention is directed to amino tetrahydro-pyridopyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
(FR)La présente invention concerne des composés d'amino-tétrahydro-pyridopyrimidine qui sont utiles en tant qu'agents thérapeutiques pour le traitement de troubles du système nerveux central associés à la phosphodiestérase 10 (PDE10). La présente invention concerne en outre l'utilisation de tels composés pour traiter des troubles neurologiques et psychiatriques, tels que la schizophrénie, la psychose ou la maladie de Huntington, et ceux associés à une hypofonction striatale ou à un dysfonctionnement des noyaux gris centraux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)