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Machine translation
1. (WO2011022103) GANGLIOSIDE EPITOPES FOR TREATING GUILLAIN-BARRE SYNDROME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/022103    International Application No.:    PCT/US2010/036374
Publication Date: 24.02.2011 International Filing Date: 27.05.2010
IPC:
C07K 14/205 (2006.01), C07K 14/47 (2006.01), C07K 16/12 (2006.01), C07K 16/42 (2006.01)
Applicants: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. [US/US]; 1120 15th Street, Ca 2126 Augusta, GA 30912 (US) (For All Designated States Except US).
YU, Robert, K. [US/US]; (US) (For US Only).
USUKI, Seigo [JP/US]; (US) (For US Only)
Inventors: YU, Robert, K.; (US).
USUKI, Seigo; (US)
Agent: PABST, Patrea L.; Pabst Patent Group LLP 1545 Peachtree Street, N.E. Suite 320 Atlanta, GA 30309 (US)
Priority Data:
61/277,297 24.09.2009 US
61/274,434 18.08.2009 US
Title (EN) GANGLIOSIDE EPITOPES FOR TREATING GUILLAIN-BARRE SYNDROME
(FR) ÉPITOPES DE GANGLIOSIDE POUR TRAITER LE SYNDROME DE GUILLAIN-BARRÉ
Abstract: front page image
(EN)Disclosed are compositions and methods for treating Guillain-Barré syndrome (GBS) in a subject that involves neutralizing specific pathogenic anti-glycolipid antibodies in the circulation of the subject. This can involve administering to the subject a molecular mimic of a ganglioside that serves as a specific competitive inhibitor for anti-ganglioside antibodies in the circulation. Also disclosed is an animal model of GBS having anti- ganglioside antibodies in the circulation.
(FR)L'invention porte sur des compositions et des procédés pour traiter le syndrome de Guillain-Barré (GBS) dans un sujet qui mettent en jeu la neutralisation d'anticorps anti-glycolipides pathogènes spécifiques dans la circulation du sujet. Ceci peut mettre en jeu l'administration au sujet d'un mimétique moléculaire d'un ganglioside qui sert d'inhibiteur compétitif spécifique pour les anticorps anti-gangliosides dans la circulation. L'invention porte également sur un modèle animal de GBS ayant des anticorps anti-gangliosides dans la circulation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)