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1. (WO2011021221) COMPOSITIONS FOR SPINAL CORD INJURY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/021221    International Application No.:    PCT/IN2010/000543
Publication Date: 24.02.2011 International Filing Date: 17.08.2010
IPC:
C12N 15/113 (2010.01), A61K 31/713 (2006.01), A61P 25/00 (2006.01)
Applicants: RELIANCE LIFE SCIENCES PVT. LTD. [IN/IN]; Dhirubhai Ambani Life Sciences Centre R-282, TTC Area of MIDC Thane Belapur Road, Rabale Navi Mumbai - 400 701 Maharashtra (IN) (For All Designated States Except US).
MURALI, Krishna, Adepalli [IN/IN]; (IN) (For US Only).
KRITI, Bimalendu, Ray [IN/IN]; (IN) (For US Only).
BHARAT, Kumar [IN/IN]; (IN) (For US Only).
SHAILAJA, Chile [IN/IN]; (IN) (For US Only).
BHARAT, Saini [IN/IN]; (IN) (For US Only).
VIKRAM, Rajagopal [IN/IN]; (IN) (For US Only).
KUMAR, Manoj, A., S. [IN/IN]; (IN) (For US Only).
VENKATA, Ramana [IN/IN]; (IN) (For US Only)
Inventors: MURALI, Krishna, Adepalli; (IN).
KRITI, Bimalendu, Ray; (IN).
BHARAT, Kumar; (IN).
SHAILAJA, Chile; (IN).
BHARAT, Saini; (IN).
VIKRAM, Rajagopal; (IN).
KUMAR, Manoj, A., S.; (IN).
VENKATA, Ramana; (IN)
Agent: PURNIMA, Malkani; Reliance Life Sciences Pvt Ltd Dhirubhai Ambani Life Sciences Centre R-282, TTC Area of MIDC Thane Belapur Road, Rabale Navi Mumbai - 400 701 Maharashtra (IN)
Priority Data:
1885/MUM/2009 17.08.2009 IN
Title (EN) COMPOSITIONS FOR SPINAL CORD INJURY
(FR) COMPOSITIONS DESTINÉES AUX LÉSIONS DE LA MOELLE ÉPINIÈRE
Abstract: front page image
(EN)This invention relates to the use of short nucleic acid molecules that modulate RhoA kinase (RhoA) expression. The invention includes compounds, compositions and methods useful for silencing the expression and activity of the RhoA gene involved in the RhoA kinase pathway. In one embodiment, the present invention provides short nucleic acid molecules, such as siRNA, which can be used in treating, preventing, or inhibiting symptoms associated with acute spinal cord injuries.
(FR)La présente invention concerne l'utilisation de molécules courtes d'acide nucléique qui modulent l'expression de la kinase RhoA (RhoA). La présente invention comprend des composés, des compositions et des procédés utiles pour réduire au silence l'expression et l'activité du gène RhoA impliqué dans la voie des kinases RhoA. Dans un mode de réalisation, la présente invention concerne des molécules courtes d'acide nucléique, tel que l'ARNsi, qui peuvent être utilisées dans le traitement, la prévention, ou l'inhibition des symptômes associés à des lésions aiguës de la moelle épinière.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)