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Machine translation
1. (WO2011021000) A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/021000    International Application No.:    PCT/GB2010/001562
Publication Date: 24.02.2011 International Filing Date: 18.08.2010
IPC:
C07D 401/04 (2006.01), A61K 31/404 (2006.01), A61K 31/405 (2006.01)
Applicants: CIPLA LIMITED [IN/IN]; Mumbai Central Mumbai 400 008 (IN) (For All Designated States Except US).
RAO, Dharmaraj Ramachandra [IN/IN]; (IN) (For US Only).
KANKAN, Rajendra Narayanrao [IN/IN]; (IN) (For US Only).
CHIKHALIKAR, Sandip Vasant [IN/IN]; (IN) (For US Only).
GHAGARE, Maruti [IN/IN]; (IN) (For US Only).
CURTIS, Philip Anthony [GB/GB]; (GB) (MW only)
Inventors: RAO, Dharmaraj Ramachandra; (IN).
KANKAN, Rajendra Narayanrao; (IN).
CHIKHALIKAR, Sandip Vasant; (IN).
GHAGARE, Maruti; (IN)
Agent: COTTRILL, Emily Elizabeth Helen; A.A. Thornton & Co 235 High Holborn London WC1V 7LE (GB)
Priority Data:
1931/MUM/2009 20.08.2009 IN
Title (EN) A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN
(FR) PROCÉDÉ DE SYNTHÈSE DU NARATRIPTAN
Abstract: front page image
(EN)The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.
(FR)La présente invention concerne un procédé de préparation du naratriptan ou d'un de ses sels, le procédé consistant à : (a) faire réagir un composé de formule (3) avec un composé de formule HCCR où Z est un groupe protecteur, Y est un groupe partant et R est un groupe trialkylsilyle, un groupe trialkylstannyle ou un halogénure de zinc (II), pour obtenir un composé de formule (4); (b) convertir le composé de formule (4) en composé de formule (5) où Z' est de l'hydrogène ou un groupe benzyle; (c) convertir le composé de formule (5) en naratriptan; et (d) facultativement convertir le naratriptan en un de ses sels. La présente invention concerne également les nouveaux composés (3) et (4) et leurs procédés de préparation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)