WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2011020183) SCREENING OF PROTEIN CANDIDATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/020183    International Application No.:    PCT/CA2010/001267
Publication Date: 24.02.2011 International Filing Date: 18.08.2010
IPC:
C12N 15/62 (2006.01), C07K 19/00 (2006.01), C40B 30/00 (2006.01), G01N 33/68 (2006.01)
Applicants: NATIONAL RESEARCH COUNCIL CANADA [CA/CA]; 1200 Montreal Road Ottawa, Ontario K1A 0R6 (CA) (For All Designated States Except US).
ZHANG, Jianbing [CA/CA]; (CA) (For US Only).
HIRAMA, Tomoko [CA/JP]; (JP) (For US Only)
Inventors: ZHANG, Jianbing; (CA).
HIRAMA, Tomoko; (JP)
Agent: PATENAUDE, Sonia; National Research Council of Canada IP Portfolio Management 1200 Montreal Road, Bldg. M58 Room EG-12 Ottawa, Ontario K1A 0R6 (CA)
Priority Data:
61/272,119 18.08.2009 US
PCT/CA2009/001501 14.10.2009 CA
Title (EN) SCREENING OF PROTEIN CANDIDATES
(FR) CRIBLAGE DE PROTÉINES CANDIDATES
Abstract: front page image
(EN)Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides s method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously. PCs are fused to a protein anchor, which is captured by the target/antigen. The captured PCs are evaluated for their expression levels, biophysical properties and affinities using conventional methods.
(FR)L'utilisation réussie d'une protéine génétiquement modifiée en thérapeutique ou dans d'autres applications industrielles nécessite que la protéine présente un bon niveau d'expression, de bonnes propriétés biophysiques et souvent, l'affinité désirée pour sa cible. A cet effet, la présente invention propose un procédé de criblage de grands nombres de protéines candidates (PC), simultanément sous leurs trois aspects. Les PC sont fusionnées à une protéine d'ancrage, qui est capturée par la cible/l'antigène. Les PC capturées sont évaluées en termes de niveau d'expression, de propriétés biophysiques et d'affinités, au moyen des procédés classiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)