US2010045511 USE OF IL-15 TO INCREASE THYMIC OUTPUT AND TO TREAT LYMPHOPENIA

1. (WO2011020047) USE OF IL-15 TO INCREASE THYMIC OUTPUT AND TO TREAT LYMPHOPENIA

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Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2011/020047		International Application No.:		PCT/US2010/045511
Publication Date:		17.02.2011		International Filing Date:		13.08.2010

IPC:

A61K 38/20 (2006.01), A61K 47/48 (2006.01), A61K 48/00 (2006.01), A61P 37/04 (2006.01)

Applicants:

THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325 Rockville, Maryland 20852-3804 (US) (For All Designated States Except US).
PAVLAKIS, George N. [US/US]; (US) (For US Only).
FELBER, Barbara K. [US/US]; (US) (For US Only).
VALENTIN, Antonio [ES/US]; (US) (For US Only).
BERGAMASCHI, Cristina [IT/US]; (US) (For US Only)

Inventors:

PAVLAKIS, George N.; (US).
FELBER, Barbara K.; (US).
VALENTIN, Antonio; (US).
BERGAMASCHI, Cristina; (US)

Agent:

LOCKYER, Jean M.; Townsend and Townsend and Crew LLP Two Embarcadero Center, 8th Floor San Francisco, California 94111 (US)

Priority Data:

61/234,152		14.08.2009		US
61/234,155		14.08.2009		US

Title

(EN) USE OF IL-15 TO INCREASE THYMIC OUTPUT AND TO TREAT LYMPHOPENIA
(FR) UTILISATION D'IL-15 POUR AMÉLIORER LA PRODUCTION THYMIQUE ET POUR TRAITER LA LYMPHOPÉNIE

Abstract:

(EN)The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15.
(FR)La présente invention concerne un procédé pour améliorer la maturation et l'exportation des lymphocytes T du tissu thymique par la mise en contact du tissu thymique avec des taux supraphysiologiques d'interleukine (IL)-15. La présente invention porte également sur des procédés pour prévenir, soulager, réduire et/ou inhiber la lymphopénie ou la déplétion périphérique des lymphocytes chez un patient en ayant besoin, par l'administration d'IL-15 au patient.

Designated States:

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

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