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Machine translation
1. (WO2011020045) COMBINED USE OF GDF TRAPS AND ERYTHROPOIETIN RECEPTOR ACTIVATORS TO INCREASE RED BLOOD CELL LEVELS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/020045    International Application No.:    PCT/US2010/045509
Publication Date: 17.02.2011 International Filing Date: 13.08.2010
IPC:
A61K 38/00 (2006.01), A61P 7/06 (2006.01), C07K 19/00 (2006.01)
Applicants: ACCELERON PHARMA INC. [US/US]; 128 Sidney Street Cambridge, MA 02139 (US) (For All Designated States Except US).
SEEHRA, Jasbir [US/US]; (US) (For US Only).
PEARSALL, Robert, Scott [US/US]; (US) (For US Only).
KUMAR, Ravindra [US/US]; (US) (For US Only)
Inventors: SEEHRA, Jasbir; (US).
PEARSALL, Robert, Scott; (US).
KUMAR, Ravindra; (US)
Agent: VARMA, Anita; Ropes & Gray LLP Prudential Tower 800 Boylston Street Boston, MA 02199-3600 (US)
Priority Data:
PCT/US2009/004659 13.08.2009 US
12/583,177 13.08.2009 US
61/305,901 18.02.2010 US
Title (EN) COMBINED USE OF GDF TRAPS AND ERYTHROPOIETIN RECEPTOR ACTIVATORS TO INCREASE RED BLOOD CELL LEVELS
(FR) UTILISATION COMBINÉE DE PIÈGES GDF ET D'ACTIVATEURS DU RÉCEPTEUR DE L'ÉRYTHROPOÏÉTINE POUR AUGMENTER LES TAUX DE GLOBULES ROUGES
Abstract: front page image
(EN)Compositions for increasing red blood cell levels or treatment of anemia comprising erythropoietin receptor activators and a variant Activin RIIB (ActRIIB) polypeptide having a leucine residue replaced by a acidic amino acid residue, where the variant ActRIIB polypeptide has a reduced affinity for activin B and may be called a GDF trap. Methods for the use of these compositions.
(FR)L'invention concerne des compositions pour augmenter les taux de globules rouges ou pour traiter l'anémie, lesdites compositions comprenant des activateurs du récepteur de l'érythropoïétine et un polypeptide variant de l'activine RIIB (ActRIIB) ayant un résidu de leucine remplacé par un résidu acide d'acide aminé, le polypeptide variant ActRIIB ayant une affinité réduite vis-à-vis de l'activine B et pouvant être appelé piège GDF. L'invention porte également sur les procédés d'utilisation de ces compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)