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Pub. No.:    WO/2011/018101    International Application No.:    PCT/EP2009/006857
Publication Date: 17.02.2011 International Filing Date: 12.08.2009
C07D 401/04 (2006.01), A61K 31/454 (2006.01)
Applicants: SYNTHON B.V. [NL/NL]; Microweg 22 NL-6545 CM Nijmegen (NL) (For All Designated States Except US).
VAN EUPEN, Jacobus, Theodorus, Henricus [NL/NL]; (NL) (For US Only)
Inventors: VAN EUPEN, Jacobus, Theodorus, Henricus; (NL)
Agent: PRINS, Hendrik, Willem; Arnold & Siedsma PO Box 18558 NL-2502 EN The Hague (NL)
Priority Data:
Abstract: front page image
(EN)The present invention relates to acid addition salts of lenalidomide, wherein said acid has a pKa lower than 1, preferably selected from hydrochloric acid, hydrobromic acid, methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid and p-toluenesulfonic acid, to processes for their making, and use in medicine, and to purification of lenalidomide base.
(FR)La présente invention concerne des sels d'addition d'acide de lénalidomide, ledit acide ayant un pKa inférieur à 1, de préférence étant choisi parmi l'acide chlorhydrique, l'acide bromhydrique, l'acide méthanesulfonique, l'acide éthanesulfonique, l'acide benzènesulfonique et l'acide p-toluènesulfonique. L'invention concerne également des procédés pour leur fabrication et leur utilisation en médecine, ainsi que la purification d'une base de lénalidomide.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)