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1. (WO2011017697) COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/017697    International Application No.:    PCT/US2010/044878
Publication Date: 10.02.2011 International Filing Date: 09.08.2010
IPC:
C12N 15/113 (2010.01), A61K 31/7088 (2006.01), A61P 17/02 (2006.01)
Applicants: NEW YORK UNIVERSITY [US/US]; 70 Washington Square South New York, NY 10012 (US) (For All Designated States Except US).
TOMIC-CANIC, Marjana [US/US]; (US) (For US Only).
BREM, Harold [US/US]; (US) (For US Only)
Inventors: TOMIC-CANIC, Marjana; (US).
BREM, Harold; (US)
Agent: PABST, Patrea, L.; Pabst Patent Group LLP 1545 Peachtree Street, N.E. Suite 320 Atlanta, GA 30309 (US)
Priority Data:
61/232,282 07.08.2009 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS
(FR) COMPOSITIONS ET MÉTHODES POUR TRAITER DES TROUBLES INFLAMMATOIRES
Abstract: front page image
(EN)Compositions and methods for antagonizing miRNAs that are overexpressed in chronic, non-healing wounds, as compared to healthy tissue, are disclosed. The miRNA antagonists are oligonucleotides that hybridize to selected pre-miENA or mature miRNAs and prevent the miRNAs from binding to and downregulating their target mRNAs. Methods of using the miRNA antagonists to treat inflammatory disorders, including to promote healing of chronic, non-healing wounds and acute wounds are provided.
(FR)La présente invention concerne des compositions et des méthodes pour exercer un effet antagoniste sur les ARNmi qui sont surexprimés dans des plaies chroniques, non cicatrisantes, par rapport au tissu sain. Les antagonistes des ARNmi sont des oligonucléotides qui s'hybrident avec des pré-ENAmi ou des ARNmi matures sélectionnés et empêchent les ARNmi de se lier et réguler à la baisse leurs ARNm cibles. La présente invention concerne en outre des procédés d'utilisation des antagonistes des ARNmi pour traiter des troubles inflammatoires, y compris pour favoriser la cicatrisation de plaies chroniques, non cicatrisantes et de plaies aiguës.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)