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Machine translation
1. (WO2011017533) CRYSTALLINE SALTS OF METHYL 2- ( (R) - ( 3-CHLORO PHENYL) ( (R) -L- ( (S) -2- (METHYLAMINO) -3- ( (R) -TETRAHYDRO-2H-PYRAN-3-YL) PROPYLCARBAMOYL )
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/017533    International Application No.:    PCT/US2010/044568
Publication Date: 10.02.2011 International Filing Date: 05.08.2010
IPC:
C07D 405/12 (2006.01), A61K 31/453 (2006.01), A61P 9/00 (2006.01)
Applicants: VITAE PHARMACEUTICALS, INC. [US/US]; 502 West Office Center Drive Fort Washington, PA 19034 (US) (For All Designated States Except US).
CLAREMON, David, A. [US/US]; (US) (For US Only).
SIMPSON, Robert, D. [US/US]; (US) (For US Only).
JIA, Lanqi [CN/US]; (US) (For US Only)
Inventors: CLAREMON, David, A.; (US).
SIMPSON, Robert, D.; (US).
JIA, Lanqi; (US)
Agent: ABELLEIRA, Susan, M.; Hamilton, Brook, Smith & Reynolds, P.C. 530 Virginia Rd. P.O. Box 9133 Concord, MA 01742-9133 (US)
Priority Data:
61/231,860 06.08.2009 US
Title (EN) CRYSTALLINE SALTS OF METHYL 2- ( (R) - ( 3-CHLORO PHENYL) ( (R) -L- ( (S) -2- (METHYLAMINO) -3- ( (R) -TETRAHYDRO-2H-PYRAN-3-YL) PROPYLCARBAMOYL )
(FR) SELS CRISTALLINS DE MÉTHYL-2-((R)-(3-CHLOROPHÉNYL)((R)-L-((S)-2-(MÉTHYLAMINO)-3-((R)-TÉTRAHYDRO-2H-PYRAN-3-YL)PROPYLCARBAMOYLE)
Abstract: front page image
(EN)Mucic acid salts of a compound represented by the following structural formula:(I) are disclosed. In particular, single crystalline mucic acid salts of the compound represented by structural formula (I) are characterized by a variety of properties and physical measurements. Methods of producing the mucic acid salts, using the salts to antagonize one or more aspartic proteases, and methods of treating a number of aspartic protease mediated disorders using the salts are described herein.
(FR)L'invention concerne des sels d'acides mucique d'un composé représenté par la formule structurale (I). En particulier, des sels d'acide mucique monocristallins du composé représenté par la formule structurale (I) sont caractérisés par une diversité de propriétés et de mesures physiques. L'invention concerne également des procédés de fabrication des sels d'acide mucique, à l'aide des sels pour antagoniser une ou plusieurs protéases aspartiques; elle concerne également des procédés de traitement d'un nombre de protéases de troubles à médiation par une protéase aspartique à l'aide des sels tel que décrit ci-dessus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)