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Machine translation
1. (WO2011017414) TRANSGENIC MOUSE KNOCKOUT FOR FVIII AND VWF - MODEL OF HEMOPHILIA A
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/017414    International Application No.:    PCT/US2010/044381
Publication Date: 10.02.2011 International Filing Date: 04.08.2010
Chapter 2 Demand Filed:    06.06.2011    
IPC:
C12N 15/85 (2006.01), A01K 67/027 (2006.01)
Applicants: BAXTER INTERNATIONAL INC. [US/US]; One Baxter Parkway Deerfield, IL 60015 (US) (For All Designated States Except US).
BAXTER HEALTHCARE S.A. [CH/CH]; Thurgauerstrasse 130 CH-8152 Glattpark (Opfikon) (CH) (For All Designated States Except US).
TURECEK, Peter [AT/AT]; (AT) (For US Only).
AHMAD, Raffi, Udin [AT/AT]; (AT) (For US Only).
GRITSCH, Herbert [AT/AT]; (AT) (For US Only).
MUCHITSCH, Eva-Maria [AT/AT]; (AT) (For US Only).
SCHWARZ, Hans-Peter [AT/AT]; (AT) (For US Only)
Inventors: TURECEK, Peter; (AT).
AHMAD, Raffi, Udin; (AT).
GRITSCH, Herbert; (AT).
MUCHITSCH, Eva-Maria; (AT).
SCHWARZ, Hans-Peter; (AT)
Agent: NEVILLE, Katherine, L.; Marshall, Gerstein & Borun LLP 233 S. Wacker Drive 6300 Willis Tower Chicago, IL 60606-6357 (US)
Priority Data:
61/231,230 04.08.2009 US
Title (EN) TRANSGENIC MOUSE KNOCKOUT FOR FVIII AND VWF - MODEL OF HEMOPHILIA A
(FR) SOURIS TRANSGÉNIQUE DÉPOURVUE DU FVIII ENDOGÈNE ET DU VWF EN TANT QUE MODÈLE DE L'HÉMOPHILIE A
Abstract: front page image
(EN)The present invention relates, generally, to a transgenic non-human animal model of hemophilia A, wherein the transgenic animal is deficient in endogenous Factor VIII and endogenous von Willebrand Factor, and methods to treat hereditary or acquired hemophilia A or von Willebrand Disease (VWD) by administration of exogenous human VWF.
(FR)La présente invention concerne, d'une manière générale, un modèle animal non humain transgénique de l'hémophilie A. Ledit animal transgénique est dépourvu du facteur endogène VIII et du facteur endogène de Willebrand. L'invention porte en outre sur des procédés de traitement de la maladie de Willebrand ou de l'hémophilie A héréditaire ou acquise, par l'administration du VWF humain exogène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)