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Machine translation
1. (WO2011017369) A LECTIN ASSAY FOR ASSESSING GLYCOFORMS AS AN EARLY MARKER IN DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/017369    International Application No.:    PCT/US2010/044307
Publication Date: 10.02.2011 International Filing Date: 03.08.2010
Chapter 2 Demand Filed:    04.03.2011    
IPC:
C12Q 1/00 (2006.01), G01N 33/569 (2006.01), C07K 1/00 (2006.01)
Applicants: INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH [US/US]; 3805 Old Easton Road Doylestown, PA 18902 (US) (For All Designated States Except US).
ROMANO, Patrick, Robert [US/US]; (US) (For US Only).
MEHTA, Anand [US/US]; (US) (For US Only).
BLOCK, Timothy, M. [US/US]; (US) (For US Only)
Inventors: ROMANO, Patrick, Robert; (US).
MEHTA, Anand; (US).
BLOCK, Timothy, M.; (US)
Agent: ACETO, Joseph, F.; Wilcox & Aceto The Pennsylvania Biotechnology Center 3805 Old Easton Road Doylestown, PA 18902 (US)
Priority Data:
61/231,400 05.08.2009 US
Title (EN) A LECTIN ASSAY FOR ASSESSING GLYCOFORMS AS AN EARLY MARKER IN DISEASE
(FR) DOSAGE DE LECTINE POUR L'ÉVALUATION DE GLYCOFORMES EN TANT QUE MARQUEUR PRÉCOCE D'UNE MALADIE
Abstract: front page image
(EN)The present invention provides methods, compositions, apparatus, and kits for assessing glycoforms of proteins as a biomarker for disease. A purified recombinant form of lectin is used as a detector molecule to specifically label target sugars expressed in disease states. The high affinity of recombinant lectin allows for automation of assays that would be used in the diagnosis of diseases such as, but not limited to, cancer or liver disease.
(FR)La présente invention concerne des procédés, des compositions, des appareils et des kits qui permettent d'évaluer des glycoformes de protéines en tant que biomarqueurs de maladie. Une forme recombinante purifiée de lectine est utilisée en tant que molécule de détecteur pour marquer spécifiquement des sucres cibles exprimés dans des pathologies. L'affinité élevée de la lectine recombinante permet l'automatisation de dosages qui seront utilisés dans le diagnostic de maladies telles que, mais non exclusivement, le cancer ou les hépatopathies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)