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Pub. No.:    WO/2011/017219    International Application No.:    PCT/US2010/043927
Publication Date: 10.02.2011 International Filing Date: 30.07.2010
A01N 43/52 (2006.01), A61K 31/415 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607 (US) (For All Designated States Except US).
GUO, Wenchang [CN/US]; (US) (For US Only).
HSIEH, Ching-Yi [--/US]; (US) (For US Only).
HUANG, Wenzhe [CN/CN]; (CN) (For US Only).
LIU, Ruiwu [US/US]; (US) (For US Only).
LAM, Kit, S. [US/US]; (US) (For US Only).
KUNG, Hsing-Jien [US/US]; (US) (For US Only).
SONG, Aimin [CN/US]; (US) (For US Only)
Inventors: GUO, Wenchang; (US).
HSIEH, Ching-Yi; (US).
HUANG, Wenzhe; (CN).
LIU, Ruiwu; (US).
LAM, Kit, S.; (US).
KUNG, Hsing-Jien; (US).
SONG, Aimin; (US)
Agent: TRIMBLE, Alexander, R.; Townsend and Townsend and Crew LLP Two Embarcadero Center, 8th Floor San Francisco, California 94111 (US)
Priority Data:
61/230,925 03.08.2009 US
Abstract: front page image
(EN)The present invention provides compounds of Formula I, as well as pharmaceutical compositions including compounds of Formula I. The present invention also provides methods of treating B-cell leukemia and lymphoma, prostate cancer, and osteoporosis. The present invention also provides methods of inhibiting Btk, Etk, Itk and Mer.
(FR)La présente invention porte sur des composés de Formule I ainsi que sur des compositions pharmaceutiques comprenant des composés de Formule I. La présente invention porte également sur des procédés de traitement d'une leucémie et d'un lymphome à cellules B, d'un cancer de la prostate et de l'ostéoporose. La présente invention porte également sur des procédés d'inhibition de Btk, Etk, Itk et Mer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)